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The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine
INTRODUCTION: Different subtypes of vaccines have been developed to help protect populations from COVID-19. Currently, three vaccines have been authorized by the United States Food and Drug Administration for emergency use to combat the COVID-19 pandemic. With COVID-19 vaccination rates increasing,...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514739/ https://www.ncbi.nlm.nih.gov/pubmed/34659871 http://dx.doi.org/10.1177/21526567211049744 |
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author | Jalil, Maaz Abraham, John M. Hostoffer, Robert |
author_facet | Jalil, Maaz Abraham, John M. Hostoffer, Robert |
author_sort | Jalil, Maaz |
collection | PubMed |
description | INTRODUCTION: Different subtypes of vaccines have been developed to help protect populations from COVID-19. Currently, three vaccines have been authorized by the United States Food and Drug Administration for emergency use to combat the COVID-19 pandemic. With COVID-19 vaccination rates increasing, it is important to know whether immunodeficient patients have the capacity to mount an immune response with the available vaccines. CASE REPORT: A 78-year-old female with Common Variable Immunodeficiency and anti-IgA antibodies who is naïve to IVIgG treatment responded positively to a COVID-19 mRNA vaccine. Successful seroconversion was proved by having positive COVID-19 spike protein IgG antibodies weeks after the vaccination. Her recent IgG, IgA, and IgM levels were all significantly reduced. Previously, she had no response to the polysaccharide pneumococcal vaccine, but did maintain titers afterTdap vaccination. DISCUSSION: Immunodeficient patients are a susceptible population during a pandemic. Unfortunately, there is a paucity of research on the infectivity, vaccination, and outcome of these patients during the COVID-19 outbreak. Our patient with CVID was able to respond to protein/toxoid vaccines, but did not respond to polysaccharide pneumococcal vaccine. After inoculation with an mRNA COVID-19 vaccine she was able to create COVID-19 spike protein IgG antibodies. CONCLUSION: We present a case of successful vaccination to COVID-19 by an mRNA vaccine in an IVIgG naïve CVID patient. |
format | Online Article Text |
id | pubmed-8514739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-85147392021-10-15 The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine Jalil, Maaz Abraham, John M. Hostoffer, Robert Allergy Rhinol (Providence) Case Report INTRODUCTION: Different subtypes of vaccines have been developed to help protect populations from COVID-19. Currently, three vaccines have been authorized by the United States Food and Drug Administration for emergency use to combat the COVID-19 pandemic. With COVID-19 vaccination rates increasing, it is important to know whether immunodeficient patients have the capacity to mount an immune response with the available vaccines. CASE REPORT: A 78-year-old female with Common Variable Immunodeficiency and anti-IgA antibodies who is naïve to IVIgG treatment responded positively to a COVID-19 mRNA vaccine. Successful seroconversion was proved by having positive COVID-19 spike protein IgG antibodies weeks after the vaccination. Her recent IgG, IgA, and IgM levels were all significantly reduced. Previously, she had no response to the polysaccharide pneumococcal vaccine, but did maintain titers afterTdap vaccination. DISCUSSION: Immunodeficient patients are a susceptible population during a pandemic. Unfortunately, there is a paucity of research on the infectivity, vaccination, and outcome of these patients during the COVID-19 outbreak. Our patient with CVID was able to respond to protein/toxoid vaccines, but did not respond to polysaccharide pneumococcal vaccine. After inoculation with an mRNA COVID-19 vaccine she was able to create COVID-19 spike protein IgG antibodies. CONCLUSION: We present a case of successful vaccination to COVID-19 by an mRNA vaccine in an IVIgG naïve CVID patient. SAGE Publications 2021-10-06 /pmc/articles/PMC8514739/ /pubmed/34659871 http://dx.doi.org/10.1177/21526567211049744 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Jalil, Maaz Abraham, John M. Hostoffer, Robert The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine |
title | The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine |
title_full | The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine |
title_fullStr | The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine |
title_full_unstemmed | The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine |
title_short | The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine |
title_sort | successful vaccination of an ivigg naive cvid patient with an mrna covid-19 vaccine |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514739/ https://www.ncbi.nlm.nih.gov/pubmed/34659871 http://dx.doi.org/10.1177/21526567211049744 |
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