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The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine

INTRODUCTION: Different subtypes of vaccines have been developed to help protect populations from COVID-19. Currently, three vaccines have been authorized by the United States Food and Drug Administration for emergency use to combat the COVID-19 pandemic. With COVID-19 vaccination rates increasing,...

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Autores principales: Jalil, Maaz, Abraham, John M., Hostoffer, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514739/
https://www.ncbi.nlm.nih.gov/pubmed/34659871
http://dx.doi.org/10.1177/21526567211049744
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author Jalil, Maaz
Abraham, John M.
Hostoffer, Robert
author_facet Jalil, Maaz
Abraham, John M.
Hostoffer, Robert
author_sort Jalil, Maaz
collection PubMed
description INTRODUCTION: Different subtypes of vaccines have been developed to help protect populations from COVID-19. Currently, three vaccines have been authorized by the United States Food and Drug Administration for emergency use to combat the COVID-19 pandemic. With COVID-19 vaccination rates increasing, it is important to know whether immunodeficient patients have the capacity to mount an immune response with the available vaccines. CASE REPORT: A 78-year-old female with Common Variable Immunodeficiency and anti-IgA antibodies who is naïve to IVIgG treatment responded positively to a COVID-19 mRNA vaccine. Successful seroconversion was proved by having positive COVID-19 spike protein IgG antibodies weeks after the vaccination. Her recent IgG, IgA, and IgM levels were all significantly reduced. Previously, she had no response to the polysaccharide pneumococcal vaccine, but did maintain titers afterTdap vaccination. DISCUSSION: Immunodeficient patients are a susceptible population during a pandemic. Unfortunately, there is a paucity of research on the infectivity, vaccination, and outcome of these patients during the COVID-19 outbreak. Our patient with CVID was able to respond to protein/toxoid vaccines, but did not respond to polysaccharide pneumococcal vaccine. After inoculation with an mRNA COVID-19 vaccine she was able to create COVID-19 spike protein IgG antibodies. CONCLUSION: We present a case of successful vaccination to COVID-19 by an mRNA vaccine in an IVIgG naïve CVID patient.
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spelling pubmed-85147392021-10-15 The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine Jalil, Maaz Abraham, John M. Hostoffer, Robert Allergy Rhinol (Providence) Case Report INTRODUCTION: Different subtypes of vaccines have been developed to help protect populations from COVID-19. Currently, three vaccines have been authorized by the United States Food and Drug Administration for emergency use to combat the COVID-19 pandemic. With COVID-19 vaccination rates increasing, it is important to know whether immunodeficient patients have the capacity to mount an immune response with the available vaccines. CASE REPORT: A 78-year-old female with Common Variable Immunodeficiency and anti-IgA antibodies who is naïve to IVIgG treatment responded positively to a COVID-19 mRNA vaccine. Successful seroconversion was proved by having positive COVID-19 spike protein IgG antibodies weeks after the vaccination. Her recent IgG, IgA, and IgM levels were all significantly reduced. Previously, she had no response to the polysaccharide pneumococcal vaccine, but did maintain titers afterTdap vaccination. DISCUSSION: Immunodeficient patients are a susceptible population during a pandemic. Unfortunately, there is a paucity of research on the infectivity, vaccination, and outcome of these patients during the COVID-19 outbreak. Our patient with CVID was able to respond to protein/toxoid vaccines, but did not respond to polysaccharide pneumococcal vaccine. After inoculation with an mRNA COVID-19 vaccine she was able to create COVID-19 spike protein IgG antibodies. CONCLUSION: We present a case of successful vaccination to COVID-19 by an mRNA vaccine in an IVIgG naïve CVID patient. SAGE Publications 2021-10-06 /pmc/articles/PMC8514739/ /pubmed/34659871 http://dx.doi.org/10.1177/21526567211049744 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Jalil, Maaz
Abraham, John M.
Hostoffer, Robert
The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine
title The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine
title_full The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine
title_fullStr The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine
title_full_unstemmed The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine
title_short The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine
title_sort successful vaccination of an ivigg naive cvid patient with an mrna covid-19 vaccine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514739/
https://www.ncbi.nlm.nih.gov/pubmed/34659871
http://dx.doi.org/10.1177/21526567211049744
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