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Primary Intraocular Lymphoma in a Patient with Bilateral Epstein-Barr Virus Panuveitis

PURPOSE: Herein, we report a case of primary intraocular lymphoma (PIOL) with the first presentation of bilateral Epstein-Barr virus- (EBV-) associated panuveitis. Case Presentation. A 69-year-old male was referred with a three-day history of blurred vision and pain and redness in his left eye follo...

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Autores principales: Hosseini, Seyedeh Maryam, Abrishami, Mojtaba, Barashki, Elham, Zamani, Ghodsieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514923/
https://www.ncbi.nlm.nih.gov/pubmed/34659852
http://dx.doi.org/10.1155/2021/9496173
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author Hosseini, Seyedeh Maryam
Abrishami, Mojtaba
Barashki, Elham
Zamani, Ghodsieh
author_facet Hosseini, Seyedeh Maryam
Abrishami, Mojtaba
Barashki, Elham
Zamani, Ghodsieh
author_sort Hosseini, Seyedeh Maryam
collection PubMed
description PURPOSE: Herein, we report a case of primary intraocular lymphoma (PIOL) with the first presentation of bilateral Epstein-Barr virus- (EBV-) associated panuveitis. Case Presentation. A 69-year-old male was referred with a three-day history of blurred vision and pain and redness in his left eye following cataract surgery. Examination revealed panuveitis, vitritis, and necrotizing retinitis with retinal hemorrhage. A month later, the right eye was also involved. Polymerase chain reaction-based analysis of the vitreous sample was positive for EBV, and cytological evaluation was compatible with the diagnosis of B-cell lymphoma. A significant improvement was observed following serial intravitreal rituximab and methotrexate injections. The central nervous system and lungs were involved after 6 months, and the patient expired despite systemic chemotherapy. CONCLUSION: There may be an association between EBV panuveitis and primary intraocular B-cell lymphoma.
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spelling pubmed-85149232021-10-15 Primary Intraocular Lymphoma in a Patient with Bilateral Epstein-Barr Virus Panuveitis Hosseini, Seyedeh Maryam Abrishami, Mojtaba Barashki, Elham Zamani, Ghodsieh Case Rep Ophthalmol Med Case Report PURPOSE: Herein, we report a case of primary intraocular lymphoma (PIOL) with the first presentation of bilateral Epstein-Barr virus- (EBV-) associated panuveitis. Case Presentation. A 69-year-old male was referred with a three-day history of blurred vision and pain and redness in his left eye following cataract surgery. Examination revealed panuveitis, vitritis, and necrotizing retinitis with retinal hemorrhage. A month later, the right eye was also involved. Polymerase chain reaction-based analysis of the vitreous sample was positive for EBV, and cytological evaluation was compatible with the diagnosis of B-cell lymphoma. A significant improvement was observed following serial intravitreal rituximab and methotrexate injections. The central nervous system and lungs were involved after 6 months, and the patient expired despite systemic chemotherapy. CONCLUSION: There may be an association between EBV panuveitis and primary intraocular B-cell lymphoma. Hindawi 2021-10-06 /pmc/articles/PMC8514923/ /pubmed/34659852 http://dx.doi.org/10.1155/2021/9496173 Text en Copyright © 2021 Seyedeh Maryam Hosseini et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hosseini, Seyedeh Maryam
Abrishami, Mojtaba
Barashki, Elham
Zamani, Ghodsieh
Primary Intraocular Lymphoma in a Patient with Bilateral Epstein-Barr Virus Panuveitis
title Primary Intraocular Lymphoma in a Patient with Bilateral Epstein-Barr Virus Panuveitis
title_full Primary Intraocular Lymphoma in a Patient with Bilateral Epstein-Barr Virus Panuveitis
title_fullStr Primary Intraocular Lymphoma in a Patient with Bilateral Epstein-Barr Virus Panuveitis
title_full_unstemmed Primary Intraocular Lymphoma in a Patient with Bilateral Epstein-Barr Virus Panuveitis
title_short Primary Intraocular Lymphoma in a Patient with Bilateral Epstein-Barr Virus Panuveitis
title_sort primary intraocular lymphoma in a patient with bilateral epstein-barr virus panuveitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514923/
https://www.ncbi.nlm.nih.gov/pubmed/34659852
http://dx.doi.org/10.1155/2021/9496173
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