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Desmoglein2 Regulates Claudin2 Expression by Sequestering PI-3-Kinase in Intestinal Epithelial Cells

Inflammation-induced reduction of intestinal desmosomal cadherin Desmoglein 2 (Dsg2) is linked to changes of tight junctions (TJ) leading to impaired intestinal epithelial barrier (IEB) function by undefined mechanisms. We characterized the interplay between loss of Dsg2 and upregulation of pore-for...

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Detalles Bibliográficos
Autores principales:	Burkard, Natalie, Meir, Michael, Kannapin, Felix, Otto, Christoph, Petzke, Maximilian, Germer, Christoph-Thomas, Waschke, Jens, Schlegel, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514949/ https://www.ncbi.nlm.nih.gov/pubmed/34659262 http://dx.doi.org/10.3389/fimmu.2021.756321

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