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iPSC culture expansion selects against putatively actionable mutations in the mitochondrial genome

Therapeutic application of induced pluripotent stem cell (iPSC) derivatives requires comprehensive assessment of the integrity of their nuclear and mitochondrial DNA (mtDNA) to exclude oncogenic potential and functional deficits. It is unknown, to which extent mtDNA variants originate from their par...

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Detalles Bibliográficos
Autores principales:	Kosanke, Maike, Davenport, Colin, Szepes, Monika, Wiehlmann, Lutz, Kohrn, Tim, Dorda, Marie, Gruber, Jonas, Menge, Kaja, Sievert, Maike, Melchert, Anna, Gruh, Ina, Göhring, Gudrun, Martin, Ulrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514965/ https://www.ncbi.nlm.nih.gov/pubmed/34560000 http://dx.doi.org/10.1016/j.stemcr.2021.08.016

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