CRISPR/Cas9/AAV9-mediated in vivo editing identifies MYC regulation of 3D genome in skeletal muscle stem cell

Skeletal muscle satellite cells (SCs) are stem cells responsible for muscle development and regeneration. Although CRISPR/Cas9 has been widely used, its application in endogenous SCs remains elusive. Here, we generate mice expressing Cas9 in SCs and achieve robust editing in juvenile SCs at the post...

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Detalles Bibliográficos
Autores principales: He, Liangqiang, Ding, Yingzhe, Zhao, Yu, So, Karl K., Peng, Xianlu L., Li, Yuying, Yuan, Jie, He, Zhiming, Chen, Xiaona, Sun, Hao, Wang, Huating
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514971/
https://www.ncbi.nlm.nih.gov/pubmed/34534448
http://dx.doi.org/10.1016/j.stemcr.2021.08.011

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