Cargando…
Outcome of 313 Czech Patients With IgA Nephropathy After Renal Transplantation
The recurrence of IgA nephropathy (IgAN) after kidney transplantation occurs in 20–35% of patients. The main aim of this study is to evaluate risk factors affecting the course of IgAN after renal biopsy of native kidney and kidney transplant. We evaluated clinical parameters and histological finding...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515028/ https://www.ncbi.nlm.nih.gov/pubmed/34659212 http://dx.doi.org/10.3389/fimmu.2021.726215 |
_version_ | 1784583529134292992 |
---|---|
author | Maixnerova, Dita Hruba, Petra Neprasova, Michaela Bednarova, Kamila Slatinska, Janka Suchanek, Miloslav Kollar, Marek Novak, Jan Tesar, Vladimir Viklicky, Ondrej |
author_facet | Maixnerova, Dita Hruba, Petra Neprasova, Michaela Bednarova, Kamila Slatinska, Janka Suchanek, Miloslav Kollar, Marek Novak, Jan Tesar, Vladimir Viklicky, Ondrej |
author_sort | Maixnerova, Dita |
collection | PubMed |
description | The recurrence of IgA nephropathy (IgAN) after kidney transplantation occurs in 20–35% of patients. The main aim of this study is to evaluate risk factors affecting the course of IgAN after renal biopsy of native kidney and kidney transplant. We evaluated clinical parameters and histological findings at the time of biopsy of native kidney and after kidney transplantation in 313 patients with IgAN with a follow-up of up to 36 years. Using hierarchical clustering method, patients with graft failure (n=50) were divided into two groups based on the mean time from kidney transplant to graft failure (11.2 versus 6.1 years). The time-to-graft failure corresponded well to the time from the renal biopsy of native kidney to end-stage renal disease (5.9 versus 0.4 years). Body mass index, proteinuria, microscopic hematuria, histological evaluation of fibrosis, and crescents at the time of renal biopsy of native kidney were the main variables for the differentiation of the two groups. Higher age of kidney-transplant donor, histological recurrence of IgAN, antibody-mediated rejection, and the onset of microscopic hematuria and proteinuria within 1 year after kidney transplant were also associated with worse graft survival in multivariate Cox regression analysis. |
format | Online Article Text |
id | pubmed-8515028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85150282021-10-15 Outcome of 313 Czech Patients With IgA Nephropathy After Renal Transplantation Maixnerova, Dita Hruba, Petra Neprasova, Michaela Bednarova, Kamila Slatinska, Janka Suchanek, Miloslav Kollar, Marek Novak, Jan Tesar, Vladimir Viklicky, Ondrej Front Immunol Immunology The recurrence of IgA nephropathy (IgAN) after kidney transplantation occurs in 20–35% of patients. The main aim of this study is to evaluate risk factors affecting the course of IgAN after renal biopsy of native kidney and kidney transplant. We evaluated clinical parameters and histological findings at the time of biopsy of native kidney and after kidney transplantation in 313 patients with IgAN with a follow-up of up to 36 years. Using hierarchical clustering method, patients with graft failure (n=50) were divided into two groups based on the mean time from kidney transplant to graft failure (11.2 versus 6.1 years). The time-to-graft failure corresponded well to the time from the renal biopsy of native kidney to end-stage renal disease (5.9 versus 0.4 years). Body mass index, proteinuria, microscopic hematuria, histological evaluation of fibrosis, and crescents at the time of renal biopsy of native kidney were the main variables for the differentiation of the two groups. Higher age of kidney-transplant donor, histological recurrence of IgAN, antibody-mediated rejection, and the onset of microscopic hematuria and proteinuria within 1 year after kidney transplant were also associated with worse graft survival in multivariate Cox regression analysis. Frontiers Media S.A. 2021-09-30 /pmc/articles/PMC8515028/ /pubmed/34659212 http://dx.doi.org/10.3389/fimmu.2021.726215 Text en Copyright © 2021 Maixnerova, Hruba, Neprasova, Bednarova, Slatinska, Suchanek, Kollar, Novak, Tesar and Viklicky https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Maixnerova, Dita Hruba, Petra Neprasova, Michaela Bednarova, Kamila Slatinska, Janka Suchanek, Miloslav Kollar, Marek Novak, Jan Tesar, Vladimir Viklicky, Ondrej Outcome of 313 Czech Patients With IgA Nephropathy After Renal Transplantation |
title | Outcome of 313 Czech Patients With IgA Nephropathy After Renal Transplantation |
title_full | Outcome of 313 Czech Patients With IgA Nephropathy After Renal Transplantation |
title_fullStr | Outcome of 313 Czech Patients With IgA Nephropathy After Renal Transplantation |
title_full_unstemmed | Outcome of 313 Czech Patients With IgA Nephropathy After Renal Transplantation |
title_short | Outcome of 313 Czech Patients With IgA Nephropathy After Renal Transplantation |
title_sort | outcome of 313 czech patients with iga nephropathy after renal transplantation |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515028/ https://www.ncbi.nlm.nih.gov/pubmed/34659212 http://dx.doi.org/10.3389/fimmu.2021.726215 |
work_keys_str_mv | AT maixnerovadita outcomeof313czechpatientswithiganephropathyafterrenaltransplantation AT hrubapetra outcomeof313czechpatientswithiganephropathyafterrenaltransplantation AT neprasovamichaela outcomeof313czechpatientswithiganephropathyafterrenaltransplantation AT bednarovakamila outcomeof313czechpatientswithiganephropathyafterrenaltransplantation AT slatinskajanka outcomeof313czechpatientswithiganephropathyafterrenaltransplantation AT suchanekmiloslav outcomeof313czechpatientswithiganephropathyafterrenaltransplantation AT kollarmarek outcomeof313czechpatientswithiganephropathyafterrenaltransplantation AT novakjan outcomeof313czechpatientswithiganephropathyafterrenaltransplantation AT tesarvladimir outcomeof313czechpatientswithiganephropathyafterrenaltransplantation AT viklickyondrej outcomeof313czechpatientswithiganephropathyafterrenaltransplantation |