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Nonuremic Calciphylaxis Associated With Hypercalcemia and Rheumatologic Diseases

Calcific uremic arteriolopathy, termed calciphylaxis, was previously considered a condition that developed mostly in patients requiring dialysis. It has now been described in kidney transplant patients, in advanced chronic kidney disease (CKD) patients not requiring dialysis, and in individuals with...

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Autores principales: Vatanapradith, Athip, Pujari, Ashwini, Morisetti, Phani, Hayat, Samina, Abreo, Kenneth, Amin, Bakhtiar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515064/
https://www.ncbi.nlm.nih.gov/pubmed/34693265
http://dx.doi.org/10.1016/j.xkme.2021.04.024
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author Vatanapradith, Athip
Pujari, Ashwini
Morisetti, Phani
Hayat, Samina
Abreo, Kenneth
Amin, Bakhtiar M.
author_facet Vatanapradith, Athip
Pujari, Ashwini
Morisetti, Phani
Hayat, Samina
Abreo, Kenneth
Amin, Bakhtiar M.
author_sort Vatanapradith, Athip
collection PubMed
description Calcific uremic arteriolopathy, termed calciphylaxis, was previously considered a condition that developed mostly in patients requiring dialysis. It has now been described in kidney transplant patients, in advanced chronic kidney disease (CKD) patients not requiring dialysis, and in individuals with maintained kidney function. We describe an individual with CKD stage 3b with hypercalcemia who presented with features highly specific for calciphylaxis based on results of a skin biopsy. The condition has high morbidity and mortality, and thus prompts immediate cessation of the offending agents or treatment of the cause. The following case and literature review demonstrates a need for a detailed assessment of patients’ risks and exposures and expanding the differential diagnosis to include calciphylaxis in nonuremic patients with necrotic ulcers with a plan for early imaging and possible biopsy.
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spelling pubmed-85150642021-10-21 Nonuremic Calciphylaxis Associated With Hypercalcemia and Rheumatologic Diseases Vatanapradith, Athip Pujari, Ashwini Morisetti, Phani Hayat, Samina Abreo, Kenneth Amin, Bakhtiar M. Kidney Med Case Report Calcific uremic arteriolopathy, termed calciphylaxis, was previously considered a condition that developed mostly in patients requiring dialysis. It has now been described in kidney transplant patients, in advanced chronic kidney disease (CKD) patients not requiring dialysis, and in individuals with maintained kidney function. We describe an individual with CKD stage 3b with hypercalcemia who presented with features highly specific for calciphylaxis based on results of a skin biopsy. The condition has high morbidity and mortality, and thus prompts immediate cessation of the offending agents or treatment of the cause. The following case and literature review demonstrates a need for a detailed assessment of patients’ risks and exposures and expanding the differential diagnosis to include calciphylaxis in nonuremic patients with necrotic ulcers with a plan for early imaging and possible biopsy. Elsevier 2021-07-13 /pmc/articles/PMC8515064/ /pubmed/34693265 http://dx.doi.org/10.1016/j.xkme.2021.04.024 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Vatanapradith, Athip
Pujari, Ashwini
Morisetti, Phani
Hayat, Samina
Abreo, Kenneth
Amin, Bakhtiar M.
Nonuremic Calciphylaxis Associated With Hypercalcemia and Rheumatologic Diseases
title Nonuremic Calciphylaxis Associated With Hypercalcemia and Rheumatologic Diseases
title_full Nonuremic Calciphylaxis Associated With Hypercalcemia and Rheumatologic Diseases
title_fullStr Nonuremic Calciphylaxis Associated With Hypercalcemia and Rheumatologic Diseases
title_full_unstemmed Nonuremic Calciphylaxis Associated With Hypercalcemia and Rheumatologic Diseases
title_short Nonuremic Calciphylaxis Associated With Hypercalcemia and Rheumatologic Diseases
title_sort nonuremic calciphylaxis associated with hypercalcemia and rheumatologic diseases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515064/
https://www.ncbi.nlm.nih.gov/pubmed/34693265
http://dx.doi.org/10.1016/j.xkme.2021.04.024
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