Computational Interspecies Translation Between Alzheimer’s Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging

Mouse models are vital for preclinical research on Alzheimer’s disease (AD) pathobiology. Many traditional models are driven by autosomal dominant mutations identified from early onset AD genetics whereas late onset and sporadic forms of the disease are predominant among human patients. Alongside on...

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Detalles Bibliográficos
Autores principales: Lee, Meelim J., Wang, Chuangqi, Carroll, Molly J., Brubaker, Douglas K., Hyman, Bradley T., Lauffenburger, Douglas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515135/
https://www.ncbi.nlm.nih.gov/pubmed/34658769
http://dx.doi.org/10.3389/fnins.2021.727784

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