Predictive Modeling of MAFLD Based on Hsp90α and the Therapeutic Application of Teprenone in a Diet-Induced Mouse Model

BACKGROUND AND AIMS: The heat shock protein (Hsp) 90α is induced by stress and regulates inflammation through multiple pathways. Elevated serum Hsp90α had been found in nonalcoholic steatohepatitis (NASH). Geranylgeranylacetone (GGA, also called teprenone) is a terpenoid derivative. It was reported...

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Detalles Bibliográficos
Autores principales: Xie, Yuan, Chen, Lu, Xu, Zhipeng, Li, Chen, Ni, Yangyue, Hou, Min, Chen, Lin, Chang, Hao, Yang, Yuxuan, Wang, Huiquan, He, Rongbo, Chen, Rourou, Qian, Li, Luo, Yan, Zhang, Ying, Li, Na, Zhu, Yuxiao, Ji, Minjun, Liu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515197/
https://www.ncbi.nlm.nih.gov/pubmed/34659125
http://dx.doi.org/10.3389/fendo.2021.743202

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