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Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state

Tuberous sclerosis complex (TSC) is an autosomal dominant cancer predisposition disorder caused by heterozygous mutations in TSC1 or TSC2 genes and characterized by mTORC1 hyperactivation. TSC-associated tumors develop after loss of heterozygosity mutations and their treatment involves the use of mT...

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Detalles Bibliográficos
Autores principales:	Rosset, Clévia, Jaeger, Mariane da Cunha, Filippi-Chiela, Eduardo, Reis, Larissa Brussa, Sartor, Ivaine Taís Sauthier, Oliveira, Cristina Brinckmann, de Farias, Caroline Brunetto, Roesler, Rafael, Ashton-Prolla, Patricia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Sociedade Brasileira de Genética 2021
Materias:	Cellular, Molecular and Developmental Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515215/ https://www.ncbi.nlm.nih.gov/pubmed/34609442 http://dx.doi.org/10.1590/1678-4685-GMB-2020-0475

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