A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes

OBJECTIVE: Protein disulfide isomerases (PDIs) are oxidoreductases that are involved in catalyzing the formation and rearrangement of disulfide bonds during protein folding. One of the PDI members is the PDI-associated 6 (PDIA6) protein, which has been shown to play a vital role in β-cell dysfunctio...

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Detalles Bibliográficos
Autores principales: Chhabra, Nirav Florian, Amend, Anna–Lena, Bastidas-Ponce, Aimée, Sabrautzki, Sibylle, Tarquis-Medina, Marta, Sachs, Stephan, Rubey, Marina, Lorenz-Depiereux, Bettina, Feuchtinger, Annette, Bakhti, Mostafa, Lickert, Heiko, Przemeck, Gerhard K.H., Hrabě de Angelis, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515296/
https://www.ncbi.nlm.nih.gov/pubmed/34487921
http://dx.doi.org/10.1016/j.molmet.2021.101334

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