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Exploration of the Role of the C-Terminal Domain of Human DNA Topoisomerase IIα in Catalytic Activity

[Image: see text] Human topoisomerase IIα (TOP2A) is a vital nuclear enzyme involved in resolving knots and tangles in DNA during replication and cell division. TOP2A is a homodimer with a symmetrical, multidomain structure. While the N-terminal and core regions of the protein are well-studied, the...

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Detalles Bibliográficos
Autores principales:	Dougherty, Ashley C., Hawaz, Mariam G., Hoang, Kristine G., Trac, Judy, Keck, Jacob M., Ayes, Carmen, Deweese, Joseph E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515377/ https://www.ncbi.nlm.nih.gov/pubmed/34660952 http://dx.doi.org/10.1021/acsomega.1c02083

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