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Association of the tissue microstructural diffusivity and translocator protein PET in Gulf War Illness

About a third of all United States veterans who served in the 1991 Gulf War (GW) report a range of chronic health symptoms including fatigue, neurocognitive symptoms, and musculoskeletal pain. There is growing evidence supporting the detrimental effects of maladaptive neuroimmune reactions in this m...

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Autores principales: Cheng, Chia-Hsin, Alshelh, Zeynab, Guan, Yi, Sullivan, Kimberly, Loggia, Marco L., Koo, Bang-Bon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515380/
https://www.ncbi.nlm.nih.gov/pubmed/34693367
http://dx.doi.org/10.1016/j.bbih.2021.100364
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author Cheng, Chia-Hsin
Alshelh, Zeynab
Guan, Yi
Sullivan, Kimberly
Loggia, Marco L.
Koo, Bang-Bon
author_facet Cheng, Chia-Hsin
Alshelh, Zeynab
Guan, Yi
Sullivan, Kimberly
Loggia, Marco L.
Koo, Bang-Bon
author_sort Cheng, Chia-Hsin
collection PubMed
description About a third of all United States veterans who served in the 1991 Gulf War (GW) report a range of chronic health symptoms including fatigue, neurocognitive symptoms, and musculoskeletal pain. There is growing evidence supporting the detrimental effects of maladaptive neuroimmune reactions in this multi-symptom illness. Indeed, recent studies using positron emission tomography (PET) using the radioligand [(11)C]PBR28, which binds the neuroinflammation marker 18 ​kDa translocator protein (TSPO), and diffusion magnetic resonance imaging (dMRI) have independently identified the anterior cingulate (ACC) and midcingulate cortices (MCC) as key regions for differentiating GWI veterans from healthy controls (HC). Here, we used integrated (i.e., simultaneous) PET/MRI imaging techniques, paired with dMRI processing methods (neurite density imaging, NDI, and free-water diffusion tensor model to single-shell high-order dMRI), to directly evaluate the relationship between ACC and MCC microstructural tissue parameters, TSPO signal and clinical parameters in the same cohorts of 10 GWI veterans and 19 ​HCs. Within the regions evaluated, TSPO signal elevations were associated with restricted diffusivity in the extracellular compartment, while clinical measures were best explained by neurite density and cellular structure complexity measures. Our study is the first to provide evidence of a relationship between PET and dMRI modalities in GWI and suggests that microstructural changes in the ACC and MCC are correlated to mood symptoms and cognitive performances in GWI veterans.
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spelling pubmed-85153802021-10-21 Association of the tissue microstructural diffusivity and translocator protein PET in Gulf War Illness Cheng, Chia-Hsin Alshelh, Zeynab Guan, Yi Sullivan, Kimberly Loggia, Marco L. Koo, Bang-Bon Brain Behav Immun Health Short Communication About a third of all United States veterans who served in the 1991 Gulf War (GW) report a range of chronic health symptoms including fatigue, neurocognitive symptoms, and musculoskeletal pain. There is growing evidence supporting the detrimental effects of maladaptive neuroimmune reactions in this multi-symptom illness. Indeed, recent studies using positron emission tomography (PET) using the radioligand [(11)C]PBR28, which binds the neuroinflammation marker 18 ​kDa translocator protein (TSPO), and diffusion magnetic resonance imaging (dMRI) have independently identified the anterior cingulate (ACC) and midcingulate cortices (MCC) as key regions for differentiating GWI veterans from healthy controls (HC). Here, we used integrated (i.e., simultaneous) PET/MRI imaging techniques, paired with dMRI processing methods (neurite density imaging, NDI, and free-water diffusion tensor model to single-shell high-order dMRI), to directly evaluate the relationship between ACC and MCC microstructural tissue parameters, TSPO signal and clinical parameters in the same cohorts of 10 GWI veterans and 19 ​HCs. Within the regions evaluated, TSPO signal elevations were associated with restricted diffusivity in the extracellular compartment, while clinical measures were best explained by neurite density and cellular structure complexity measures. Our study is the first to provide evidence of a relationship between PET and dMRI modalities in GWI and suggests that microstructural changes in the ACC and MCC are correlated to mood symptoms and cognitive performances in GWI veterans. Elsevier 2021-10-06 /pmc/articles/PMC8515380/ /pubmed/34693367 http://dx.doi.org/10.1016/j.bbih.2021.100364 Text en © 2021 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Cheng, Chia-Hsin
Alshelh, Zeynab
Guan, Yi
Sullivan, Kimberly
Loggia, Marco L.
Koo, Bang-Bon
Association of the tissue microstructural diffusivity and translocator protein PET in Gulf War Illness
title Association of the tissue microstructural diffusivity and translocator protein PET in Gulf War Illness
title_full Association of the tissue microstructural diffusivity and translocator protein PET in Gulf War Illness
title_fullStr Association of the tissue microstructural diffusivity and translocator protein PET in Gulf War Illness
title_full_unstemmed Association of the tissue microstructural diffusivity and translocator protein PET in Gulf War Illness
title_short Association of the tissue microstructural diffusivity and translocator protein PET in Gulf War Illness
title_sort association of the tissue microstructural diffusivity and translocator protein pet in gulf war illness
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515380/
https://www.ncbi.nlm.nih.gov/pubmed/34693367
http://dx.doi.org/10.1016/j.bbih.2021.100364
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