Copper-Promoted Conjugate Addition of Carboxylic Acids to Ethenesulfonyl Fluoride (ESF) for Constructing Aliphatic Sulfonyl Fluorides

[Image: see text] A CuO-promoted direct hydrocarboxylation of ethenesulfonyl fluoride (ESF) was developed using carboxylic acid as a nucleophile under mild conditions. A variety of molecules containing both ester group and aliphatic sulfonyl fluoride moiety exhibit great potential in medicinal chemi...

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Autores principales: Zhang, Xu, Huang, Yu-Mei, Qin, Hua-Li, Baoguo, Zhang, Rakesh, K. P., Tang, Haolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515394/
https://www.ncbi.nlm.nih.gov/pubmed/34660959
http://dx.doi.org/10.1021/acsomega.1c02804
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author Zhang, Xu
Huang, Yu-Mei
Qin, Hua-Li
Baoguo, Zhang
Rakesh, K. P.
Tang, Haolin
author_facet Zhang, Xu
Huang, Yu-Mei
Qin, Hua-Li
Baoguo, Zhang
Rakesh, K. P.
Tang, Haolin
author_sort Zhang, Xu
collection PubMed
description [Image: see text] A CuO-promoted direct hydrocarboxylation of ethenesulfonyl fluoride (ESF) was developed using carboxylic acid as a nucleophile under mild conditions. A variety of molecules containing both ester group and aliphatic sulfonyl fluoride moiety exhibit great potential in medicinal chemistry and chemical biology. Furthermore, the modification of the known drugs Ibuprofen and Aspirin was also demonstrated.
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spelling pubmed-85153942021-10-15 Copper-Promoted Conjugate Addition of Carboxylic Acids to Ethenesulfonyl Fluoride (ESF) for Constructing Aliphatic Sulfonyl Fluorides Zhang, Xu Huang, Yu-Mei Qin, Hua-Li Baoguo, Zhang Rakesh, K. P. Tang, Haolin ACS Omega [Image: see text] A CuO-promoted direct hydrocarboxylation of ethenesulfonyl fluoride (ESF) was developed using carboxylic acid as a nucleophile under mild conditions. A variety of molecules containing both ester group and aliphatic sulfonyl fluoride moiety exhibit great potential in medicinal chemistry and chemical biology. Furthermore, the modification of the known drugs Ibuprofen and Aspirin was also demonstrated. American Chemical Society 2021-09-27 /pmc/articles/PMC8515394/ /pubmed/34660959 http://dx.doi.org/10.1021/acsomega.1c02804 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Zhang, Xu
Huang, Yu-Mei
Qin, Hua-Li
Baoguo, Zhang
Rakesh, K. P.
Tang, Haolin
Copper-Promoted Conjugate Addition of Carboxylic Acids to Ethenesulfonyl Fluoride (ESF) for Constructing Aliphatic Sulfonyl Fluorides
title Copper-Promoted Conjugate Addition of Carboxylic Acids to Ethenesulfonyl Fluoride (ESF) for Constructing Aliphatic Sulfonyl Fluorides
title_full Copper-Promoted Conjugate Addition of Carboxylic Acids to Ethenesulfonyl Fluoride (ESF) for Constructing Aliphatic Sulfonyl Fluorides
title_fullStr Copper-Promoted Conjugate Addition of Carboxylic Acids to Ethenesulfonyl Fluoride (ESF) for Constructing Aliphatic Sulfonyl Fluorides
title_full_unstemmed Copper-Promoted Conjugate Addition of Carboxylic Acids to Ethenesulfonyl Fluoride (ESF) for Constructing Aliphatic Sulfonyl Fluorides
title_short Copper-Promoted Conjugate Addition of Carboxylic Acids to Ethenesulfonyl Fluoride (ESF) for Constructing Aliphatic Sulfonyl Fluorides
title_sort copper-promoted conjugate addition of carboxylic acids to ethenesulfonyl fluoride (esf) for constructing aliphatic sulfonyl fluorides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515394/
https://www.ncbi.nlm.nih.gov/pubmed/34660959
http://dx.doi.org/10.1021/acsomega.1c02804
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