Ultrasound-Assisted Iodination of Imidazo[1,2-α]pyridines Via C–H Functionalization Mediated by tert-Butyl Hydroperoxide

[Image: see text] A novel metal catalyst-free and environmentally friendly method for the regioselective iodination of imidazo[1,2-α]pyridines at their C3 position is disclosed, which has a wide substrate scope and could be sustainable. This reaction proceeds through ultrasound acceleration in the p...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Hua, Huang, Ning, Wang, Nengqing, Shen, Haicheng, Teng, Fan, Liu, Xiaoying, Jiang, Hongmei, Tan, Mei-Chen, Gui, Qing-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515396/
https://www.ncbi.nlm.nih.gov/pubmed/34660956
http://dx.doi.org/10.1021/acsomega.1c02645
_version_ 1784583604195557376
author Yang, Hua
Huang, Ning
Wang, Nengqing
Shen, Haicheng
Teng, Fan
Liu, Xiaoying
Jiang, Hongmei
Tan, Mei-Chen
Gui, Qing-Wen
author_facet Yang, Hua
Huang, Ning
Wang, Nengqing
Shen, Haicheng
Teng, Fan
Liu, Xiaoying
Jiang, Hongmei
Tan, Mei-Chen
Gui, Qing-Wen
author_sort Yang, Hua
collection PubMed
description [Image: see text] A novel metal catalyst-free and environmentally friendly method for the regioselective iodination of imidazo[1,2-α]pyridines at their C3 position is disclosed, which has a wide substrate scope and could be sustainable. This reaction proceeds through ultrasound acceleration in the presence of a green alcohol solvent. Compared with a conventional heating system, the reaction efficiency and the rate are significantly improved and the iodine atom economy is maximized using ultrasound techniques.
format Online
Article
Text
id pubmed-8515396
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-85153962021-10-15 Ultrasound-Assisted Iodination of Imidazo[1,2-α]pyridines Via C–H Functionalization Mediated by tert-Butyl Hydroperoxide Yang, Hua Huang, Ning Wang, Nengqing Shen, Haicheng Teng, Fan Liu, Xiaoying Jiang, Hongmei Tan, Mei-Chen Gui, Qing-Wen ACS Omega [Image: see text] A novel metal catalyst-free and environmentally friendly method for the regioselective iodination of imidazo[1,2-α]pyridines at their C3 position is disclosed, which has a wide substrate scope and could be sustainable. This reaction proceeds through ultrasound acceleration in the presence of a green alcohol solvent. Compared with a conventional heating system, the reaction efficiency and the rate are significantly improved and the iodine atom economy is maximized using ultrasound techniques. American Chemical Society 2021-09-28 /pmc/articles/PMC8515396/ /pubmed/34660956 http://dx.doi.org/10.1021/acsomega.1c02645 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Yang, Hua
Huang, Ning
Wang, Nengqing
Shen, Haicheng
Teng, Fan
Liu, Xiaoying
Jiang, Hongmei
Tan, Mei-Chen
Gui, Qing-Wen
Ultrasound-Assisted Iodination of Imidazo[1,2-α]pyridines Via C–H Functionalization Mediated by tert-Butyl Hydroperoxide
title Ultrasound-Assisted Iodination of Imidazo[1,2-α]pyridines Via C–H Functionalization Mediated by tert-Butyl Hydroperoxide
title_full Ultrasound-Assisted Iodination of Imidazo[1,2-α]pyridines Via C–H Functionalization Mediated by tert-Butyl Hydroperoxide
title_fullStr Ultrasound-Assisted Iodination of Imidazo[1,2-α]pyridines Via C–H Functionalization Mediated by tert-Butyl Hydroperoxide
title_full_unstemmed Ultrasound-Assisted Iodination of Imidazo[1,2-α]pyridines Via C–H Functionalization Mediated by tert-Butyl Hydroperoxide
title_short Ultrasound-Assisted Iodination of Imidazo[1,2-α]pyridines Via C–H Functionalization Mediated by tert-Butyl Hydroperoxide
title_sort ultrasound-assisted iodination of imidazo[1,2-α]pyridines via c–h functionalization mediated by tert-butyl hydroperoxide
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515396/
https://www.ncbi.nlm.nih.gov/pubmed/34660956
http://dx.doi.org/10.1021/acsomega.1c02645
work_keys_str_mv AT yanghua ultrasoundassistediodinationofimidazo12apyridinesviachfunctionalizationmediatedbytertbutylhydroperoxide
AT huangning ultrasoundassistediodinationofimidazo12apyridinesviachfunctionalizationmediatedbytertbutylhydroperoxide
AT wangnengqing ultrasoundassistediodinationofimidazo12apyridinesviachfunctionalizationmediatedbytertbutylhydroperoxide
AT shenhaicheng ultrasoundassistediodinationofimidazo12apyridinesviachfunctionalizationmediatedbytertbutylhydroperoxide
AT tengfan ultrasoundassistediodinationofimidazo12apyridinesviachfunctionalizationmediatedbytertbutylhydroperoxide
AT liuxiaoying ultrasoundassistediodinationofimidazo12apyridinesviachfunctionalizationmediatedbytertbutylhydroperoxide
AT jianghongmei ultrasoundassistediodinationofimidazo12apyridinesviachfunctionalizationmediatedbytertbutylhydroperoxide
AT tanmeichen ultrasoundassistediodinationofimidazo12apyridinesviachfunctionalizationmediatedbytertbutylhydroperoxide
AT guiqingwen ultrasoundassistediodinationofimidazo12apyridinesviachfunctionalizationmediatedbytertbutylhydroperoxide

Ejemplares similares