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Integration features of intact latent HIV-1 in CD4(+) T cell clones contribute to viral persistence

Latent intact HIV-1 proviruses persist in a small subset of long-lived CD4(+) T cells that can undergo clonal expansion in vivo. Expanded clones of CD4(+) T cells dominate latent reservoirs in individuals on long-term antiretroviral therapy (ART) and represent a major barrier to HIV-1 cure. To deter...

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Detalles Bibliográficos
Autores principales:	Huang, Amy S., Ramos, Victor, Oliveira, Thiago Y., Gaebler, Christian, Jankovic, Mila, Nussenzweig, Michel C., Cohn, Lillian B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515646/ https://www.ncbi.nlm.nih.gov/pubmed/34636876 http://dx.doi.org/10.1084/jem.20211427

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