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ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state

KCNQ1 is a pore-forming K(+) channel subunit critically important to cardiac repolarization at high heart rates. (2R)-N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2 piperidinecarboxamide, or ML277, is an activator of this channel that rescues function of pathophysiologically impo...

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Detalles Bibliográficos
Autores principales:	Eldstrom, Jodene, McAfee, Donald A., Dou, Ying, Wang, Yundi, Fedida, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515649/ https://www.ncbi.nlm.nih.gov/pubmed/34636894 http://dx.doi.org/10.1085/jgp.202112969

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