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3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation

BACKGROUND: Triple negative breast cancer (TNBC) poses a serious clinical challenge as it is an aggressive form of the disease that lacks estrogen receptor, progesterone receptor, and ERBB2 (formerly HER2) gene amplification, which limits the treatment options. The Warburg phenotype of upregulated g...

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Detalles Bibliográficos
Autores principales:	Skaripa-Koukelli, Irini, Hauton, David, Walsby-Tickle, John, Thomas, Eloïse, Owen, Joshua, Lakshminarayanan, Abirami, Able, Sarah, McCullagh, James, Carlisle, Robert C., Vallis, Katherine A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515664/ https://www.ncbi.nlm.nih.gov/pubmed/34649623 http://dx.doi.org/10.1186/s40170-021-00273-6

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