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Contemporary treatment patterns and survival of cervical cancer patients in Ethiopia
BACKGROUND: Cervical cancer is the second commonly diagnosed cancer and the second leading cause of cancer death in women in Ethiopia, with rates among the highest worldwide. However, there are limited data on cervical cancer treatment patterns and survival in the country. Herein, we examine treatme...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515694/ https://www.ncbi.nlm.nih.gov/pubmed/34645407 http://dx.doi.org/10.1186/s12885-021-08817-1 |
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author | Deressa, Biniyam Tefera Assefa, Mathewos Tafesse, Ephrem Kantelhardt, Eva Johanna Soldatovic, Ivan Cihoric, Nikola Rauch, Daniel Jemal, Ahmedin |
author_facet | Deressa, Biniyam Tefera Assefa, Mathewos Tafesse, Ephrem Kantelhardt, Eva Johanna Soldatovic, Ivan Cihoric, Nikola Rauch, Daniel Jemal, Ahmedin |
author_sort | Deressa, Biniyam Tefera |
collection | PubMed |
description | BACKGROUND: Cervical cancer is the second commonly diagnosed cancer and the second leading cause of cancer death in women in Ethiopia, with rates among the highest worldwide. However, there are limited data on cervical cancer treatment patterns and survival in the country. Herein, we examine treatment patterns and survival of cervical cancer patients treated in Tikur Anbessa Hospital Radiotherapy Center (TAHRC), the only hospital with radiotherapy facility in the country. METHODS: Women with histologically verified cervical cancer who were seen in 2014 (January 1, 2014 to December 31, 2014) at TAHRC were included. Information about clinical characteristics and treatments were extracted from the patients’ medical record files. The information on vital status was obtained from medical chart and through telephone calls. RESULT: Among 242 patients included in the study, the median age at diagnosis was 48 years. The median waiting time for radiotherapy was 5.6 months (range 2 to 9 months). Stage migration occurred in 13% of patients while waiting for radiotherapy. Consequently, the proportion of patients with stage III or IV disease increased from 66% at first consultation to 74% at the initiation of radiotherapy. Among 151 patients treated with curative intent, only 34 (22.5%) of the patients received concurrent chemotherapy while the reaming patients received radiotherapy alone. The 5-year overall survival rate was 28.4% (20.5% in the worst-case scenario). As expected, survival was lower in patients with advanced stage at initiation of radiotherapy and in those treated as palliative care. CONCLUSION: The survival of cervical cancer patients remains low in Ethiopia because of late presentation and delay in receipt of radiotherapy, leading to stage migration in substantial proportion of the cases. Concerted and coordinated multisectoral efforts are needed to promote early presentation of cervical cancer and to shorten the unacceptable, long waiting time for radiotherapy. |
format | Online Article Text |
id | pubmed-8515694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-85156942021-10-20 Contemporary treatment patterns and survival of cervical cancer patients in Ethiopia Deressa, Biniyam Tefera Assefa, Mathewos Tafesse, Ephrem Kantelhardt, Eva Johanna Soldatovic, Ivan Cihoric, Nikola Rauch, Daniel Jemal, Ahmedin BMC Cancer Research BACKGROUND: Cervical cancer is the second commonly diagnosed cancer and the second leading cause of cancer death in women in Ethiopia, with rates among the highest worldwide. However, there are limited data on cervical cancer treatment patterns and survival in the country. Herein, we examine treatment patterns and survival of cervical cancer patients treated in Tikur Anbessa Hospital Radiotherapy Center (TAHRC), the only hospital with radiotherapy facility in the country. METHODS: Women with histologically verified cervical cancer who were seen in 2014 (January 1, 2014 to December 31, 2014) at TAHRC were included. Information about clinical characteristics and treatments were extracted from the patients’ medical record files. The information on vital status was obtained from medical chart and through telephone calls. RESULT: Among 242 patients included in the study, the median age at diagnosis was 48 years. The median waiting time for radiotherapy was 5.6 months (range 2 to 9 months). Stage migration occurred in 13% of patients while waiting for radiotherapy. Consequently, the proportion of patients with stage III or IV disease increased from 66% at first consultation to 74% at the initiation of radiotherapy. Among 151 patients treated with curative intent, only 34 (22.5%) of the patients received concurrent chemotherapy while the reaming patients received radiotherapy alone. The 5-year overall survival rate was 28.4% (20.5% in the worst-case scenario). As expected, survival was lower in patients with advanced stage at initiation of radiotherapy and in those treated as palliative care. CONCLUSION: The survival of cervical cancer patients remains low in Ethiopia because of late presentation and delay in receipt of radiotherapy, leading to stage migration in substantial proportion of the cases. Concerted and coordinated multisectoral efforts are needed to promote early presentation of cervical cancer and to shorten the unacceptable, long waiting time for radiotherapy. BioMed Central 2021-10-13 /pmc/articles/PMC8515694/ /pubmed/34645407 http://dx.doi.org/10.1186/s12885-021-08817-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Deressa, Biniyam Tefera Assefa, Mathewos Tafesse, Ephrem Kantelhardt, Eva Johanna Soldatovic, Ivan Cihoric, Nikola Rauch, Daniel Jemal, Ahmedin Contemporary treatment patterns and survival of cervical cancer patients in Ethiopia |
title | Contemporary treatment patterns and survival of cervical cancer patients in Ethiopia |
title_full | Contemporary treatment patterns and survival of cervical cancer patients in Ethiopia |
title_fullStr | Contemporary treatment patterns and survival of cervical cancer patients in Ethiopia |
title_full_unstemmed | Contemporary treatment patterns and survival of cervical cancer patients in Ethiopia |
title_short | Contemporary treatment patterns and survival of cervical cancer patients in Ethiopia |
title_sort | contemporary treatment patterns and survival of cervical cancer patients in ethiopia |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515694/ https://www.ncbi.nlm.nih.gov/pubmed/34645407 http://dx.doi.org/10.1186/s12885-021-08817-1 |
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