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Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains

Alterations in the canonical processing of Amyloid Precursor Protein generate proteoforms that contribute to the onset of Alzheimer’s Disease. Modified composition of γ-secretase or mutations in its subunits has been directly linked to altered generation of Amyloid beta. Despite biochemical evidence...

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Detalles Bibliográficos
Autores principales:	Kedia, Shekhar, Mandal, Kousik, Netrakanti, Pallavi Rao, Jose, Mini, Sisodia, Sangram S., Nair, Deepak
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Micro Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515736/ https://www.ncbi.nlm.nih.gov/pubmed/34645511 http://dx.doi.org/10.1186/s13041-021-00855-x

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