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Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome
BACKGROUND: Complement activation has been associated with atherosclerosis, atherosclerotic plaque destabilization and increased risk of cardiovascular events. Complement component 7 (CC7) binds to the C5bC6 complex which is part of the terminal complement complex (TCC/C5b-9). High-sensitivity C-rea...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515738/ https://www.ncbi.nlm.nih.gov/pubmed/34649504 http://dx.doi.org/10.1186/s12872-021-02306-w |
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author | Aarsetøy, Reidun Ueland, Thor Aukrust, Pål Michelsen, Annika E. Leon de la Fuente, Ricardo Grundt, Heidi Staines, Harry Nygaard, Ottar Nilsen, Dennis W. T. |
author_facet | Aarsetøy, Reidun Ueland, Thor Aukrust, Pål Michelsen, Annika E. Leon de la Fuente, Ricardo Grundt, Heidi Staines, Harry Nygaard, Ottar Nilsen, Dennis W. T. |
author_sort | Aarsetøy, Reidun |
collection | PubMed |
description | BACKGROUND: Complement activation has been associated with atherosclerosis, atherosclerotic plaque destabilization and increased risk of cardiovascular events. Complement component 7 (CC7) binds to the C5bC6 complex which is part of the terminal complement complex (TCC/C5b-9). High-sensitivity C-reactive protein (hsCRP) is a sensitive marker of systemic inflammation and may reflect the increased inflammatory state associated with cardiovascular disease. AIM: To evaluate the associations between CC7 and total- and cardiac mortality in patients hospitalized with chest-pain of suspected coronary origin, and whether combining CC7 with hsCRP adds prognostic information. METHODS: Baseline levels of CC7 were related to 60-months survival in a prospective, observational study of 982 patients hospitalized with a suspected acute coronary syndrome (ACS) at 9 hospitals in Salta, Argentina. A cox regression model, adjusting for conventional cardiovascular risk factors, was fitted with all-cause mortality, cardiac death and sudden cardiac death (SCD) as the dependent variables. A similar Norwegian population of 871 patients was applied to test the reproducibility of results in relation to total death. RESULTS: At follow-up, 173 patients (17.7%) in the Argentinean cohort had died, of these 92 (9.4%) were classified as cardiac death and 59 (6.0%) as SCD. In the Norwegian population, a total of 254 patients (30%) died. In multivariable analysis, CC7 was significantly associated with 60-months all-cause mortality [hazard ratio (HR) 1.26 (95% confidence interval (CI), 1.07–1.47) and cardiac death [HR 1.28 (95% CI 1.02–1.60)], but not with SCD. CC7 was only weakly correlated with hsCRP (r = 0.10, p = 0.002), and there was no statistically significant interaction between the two biomarkers in relation to outcome. The significant association of CC7 with total death was reproduced in the Norwegian population. CONCLUSIONS: CC7 was significantly associated with all-cause mortality and cardiac death at 60-months follow-up in chest-pain patients with suspected ACS. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01377402, NCT00521976. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-021-02306-w. |
format | Online Article Text |
id | pubmed-8515738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-85157382021-10-20 Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome Aarsetøy, Reidun Ueland, Thor Aukrust, Pål Michelsen, Annika E. Leon de la Fuente, Ricardo Grundt, Heidi Staines, Harry Nygaard, Ottar Nilsen, Dennis W. T. BMC Cardiovasc Disord Research BACKGROUND: Complement activation has been associated with atherosclerosis, atherosclerotic plaque destabilization and increased risk of cardiovascular events. Complement component 7 (CC7) binds to the C5bC6 complex which is part of the terminal complement complex (TCC/C5b-9). High-sensitivity C-reactive protein (hsCRP) is a sensitive marker of systemic inflammation and may reflect the increased inflammatory state associated with cardiovascular disease. AIM: To evaluate the associations between CC7 and total- and cardiac mortality in patients hospitalized with chest-pain of suspected coronary origin, and whether combining CC7 with hsCRP adds prognostic information. METHODS: Baseline levels of CC7 were related to 60-months survival in a prospective, observational study of 982 patients hospitalized with a suspected acute coronary syndrome (ACS) at 9 hospitals in Salta, Argentina. A cox regression model, adjusting for conventional cardiovascular risk factors, was fitted with all-cause mortality, cardiac death and sudden cardiac death (SCD) as the dependent variables. A similar Norwegian population of 871 patients was applied to test the reproducibility of results in relation to total death. RESULTS: At follow-up, 173 patients (17.7%) in the Argentinean cohort had died, of these 92 (9.4%) were classified as cardiac death and 59 (6.0%) as SCD. In the Norwegian population, a total of 254 patients (30%) died. In multivariable analysis, CC7 was significantly associated with 60-months all-cause mortality [hazard ratio (HR) 1.26 (95% confidence interval (CI), 1.07–1.47) and cardiac death [HR 1.28 (95% CI 1.02–1.60)], but not with SCD. CC7 was only weakly correlated with hsCRP (r = 0.10, p = 0.002), and there was no statistically significant interaction between the two biomarkers in relation to outcome. The significant association of CC7 with total death was reproduced in the Norwegian population. CONCLUSIONS: CC7 was significantly associated with all-cause mortality and cardiac death at 60-months follow-up in chest-pain patients with suspected ACS. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01377402, NCT00521976. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-021-02306-w. BioMed Central 2021-10-14 /pmc/articles/PMC8515738/ /pubmed/34649504 http://dx.doi.org/10.1186/s12872-021-02306-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Aarsetøy, Reidun Ueland, Thor Aukrust, Pål Michelsen, Annika E. Leon de la Fuente, Ricardo Grundt, Heidi Staines, Harry Nygaard, Ottar Nilsen, Dennis W. T. Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome |
title | Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome |
title_full | Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome |
title_fullStr | Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome |
title_full_unstemmed | Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome |
title_short | Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome |
title_sort | complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515738/ https://www.ncbi.nlm.nih.gov/pubmed/34649504 http://dx.doi.org/10.1186/s12872-021-02306-w |
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