Catalyst-Free Visible-Light-Promoted Cyclization of Aldehydes: Access to 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives

[Image: see text] An efficient synthesis of a variety of 2,5-disubstituted 1,3,4-oxadiazole derivatives via a cyclization reaction by photoredox catalysis between aldehydes and hypervalent iodine(III) reagents is described. The reaction proceeds under mild conditions and affords various target compo...

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Autores principales: Li, Jian, Wen, Jin-Xia, Lu, Xue-Chen, Hou, Guo-Quan, Gao, Xu, Li, Yang, Liu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515816/
https://www.ncbi.nlm.nih.gov/pubmed/34661023
http://dx.doi.org/10.1021/acsomega.1c04098
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author Li, Jian
Wen, Jin-Xia
Lu, Xue-Chen
Hou, Guo-Quan
Gao, Xu
Li, Yang
Liu, Li
author_facet Li, Jian
Wen, Jin-Xia
Lu, Xue-Chen
Hou, Guo-Quan
Gao, Xu
Li, Yang
Liu, Li
author_sort Li, Jian
collection PubMed
description [Image: see text] An efficient synthesis of a variety of 2,5-disubstituted 1,3,4-oxadiazole derivatives via a cyclization reaction by photoredox catalysis between aldehydes and hypervalent iodine(III) reagents is described. The reaction proceeds under mild conditions and affords various target compounds in excellent yields. The commercially available aldehydes without preactivation and a simple visible-light-promoted procedure without any catalysts make this strategy an alternative to the conventional methods.
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spelling pubmed-85158162021-10-15 Catalyst-Free Visible-Light-Promoted Cyclization of Aldehydes: Access to 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives Li, Jian Wen, Jin-Xia Lu, Xue-Chen Hou, Guo-Quan Gao, Xu Li, Yang Liu, Li ACS Omega [Image: see text] An efficient synthesis of a variety of 2,5-disubstituted 1,3,4-oxadiazole derivatives via a cyclization reaction by photoredox catalysis between aldehydes and hypervalent iodine(III) reagents is described. The reaction proceeds under mild conditions and affords various target compounds in excellent yields. The commercially available aldehydes without preactivation and a simple visible-light-promoted procedure without any catalysts make this strategy an alternative to the conventional methods. American Chemical Society 2021-09-30 /pmc/articles/PMC8515816/ /pubmed/34661023 http://dx.doi.org/10.1021/acsomega.1c04098 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Li, Jian
Wen, Jin-Xia
Lu, Xue-Chen
Hou, Guo-Quan
Gao, Xu
Li, Yang
Liu, Li
Catalyst-Free Visible-Light-Promoted Cyclization of Aldehydes: Access to 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives
title Catalyst-Free Visible-Light-Promoted Cyclization of Aldehydes: Access to 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives
title_full Catalyst-Free Visible-Light-Promoted Cyclization of Aldehydes: Access to 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives
title_fullStr Catalyst-Free Visible-Light-Promoted Cyclization of Aldehydes: Access to 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives
title_full_unstemmed Catalyst-Free Visible-Light-Promoted Cyclization of Aldehydes: Access to 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives
title_short Catalyst-Free Visible-Light-Promoted Cyclization of Aldehydes: Access to 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives
title_sort catalyst-free visible-light-promoted cyclization of aldehydes: access to 2,5-disubstituted 1,3,4-oxadiazole derivatives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515816/
https://www.ncbi.nlm.nih.gov/pubmed/34661023
http://dx.doi.org/10.1021/acsomega.1c04098
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