Long-term survival after repetitive lymphadenectomy for nodal recurrence of pancreatic neuroendocrine neoplasms: a report of two cases

Pancreatic neuroendocrine neoplasms (PNENs) are rare, but their incidence has increased in recent years. Curative surgery is recommended in several global guidelines for resectable PNENs. Lymph node recurrence after R0 resection for PNENs is infrequent, and global guidelines recommend surgical resec...

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Autores principales: Hane, Yuma, Tsuchikawa, Takahiro, Takeuchi, Satoshi, Tanaka, Kimitaka, Nakanishi, Yoshitsugu, Asano, Toshimichi, Noji, Takehiro, Kurashima, Yo, Ebihara, Yuma, Murakami, Soichi, Nakamura, Toru, Okamura, Keisuke, Shichinohe, Toshiaki, Hirano, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515837/
https://www.ncbi.nlm.nih.gov/pubmed/34659739
http://dx.doi.org/10.1093/jscr/rjab446
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author Hane, Yuma
Tsuchikawa, Takahiro
Takeuchi, Satoshi
Tanaka, Kimitaka
Nakanishi, Yoshitsugu
Asano, Toshimichi
Noji, Takehiro
Kurashima, Yo
Ebihara, Yuma
Murakami, Soichi
Nakamura, Toru
Okamura, Keisuke
Shichinohe, Toshiaki
Hirano, Satoshi
author_facet Hane, Yuma
Tsuchikawa, Takahiro
Takeuchi, Satoshi
Tanaka, Kimitaka
Nakanishi, Yoshitsugu
Asano, Toshimichi
Noji, Takehiro
Kurashima, Yo
Ebihara, Yuma
Murakami, Soichi
Nakamura, Toru
Okamura, Keisuke
Shichinohe, Toshiaki
Hirano, Satoshi
author_sort Hane, Yuma
collection PubMed
description Pancreatic neuroendocrine neoplasms (PNENs) are rare, but their incidence has increased in recent years. Curative surgery is recommended in several global guidelines for resectable PNENs. Lymph node recurrence after R0 resection for PNENs is infrequent, and global guidelines recommend surgical resection for recurrence, if resectable. However, data on the prognosis after surgical resection for nodal recurrence of PNENs are limited. We herein report two cases in which long-term survival was achieved after repetitive lymphadenectomy for nodal recurrence of PNENs. In both cases, the pathological findings for primary PNEN showed well-differentiated neuroendocrine neoplasms and R0 resection was successfully performed. The Ki-67 index increased with each resection in both cases. Both patients showed long-term survival (10 and 14 years, respectively). Repetitive lymphadenectomy for nodal recurrence of PNENs may improve patient prognosis.
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spelling pubmed-85158372021-10-15 Long-term survival after repetitive lymphadenectomy for nodal recurrence of pancreatic neuroendocrine neoplasms: a report of two cases Hane, Yuma Tsuchikawa, Takahiro Takeuchi, Satoshi Tanaka, Kimitaka Nakanishi, Yoshitsugu Asano, Toshimichi Noji, Takehiro Kurashima, Yo Ebihara, Yuma Murakami, Soichi Nakamura, Toru Okamura, Keisuke Shichinohe, Toshiaki Hirano, Satoshi J Surg Case Rep Case Series Pancreatic neuroendocrine neoplasms (PNENs) are rare, but their incidence has increased in recent years. Curative surgery is recommended in several global guidelines for resectable PNENs. Lymph node recurrence after R0 resection for PNENs is infrequent, and global guidelines recommend surgical resection for recurrence, if resectable. However, data on the prognosis after surgical resection for nodal recurrence of PNENs are limited. We herein report two cases in which long-term survival was achieved after repetitive lymphadenectomy for nodal recurrence of PNENs. In both cases, the pathological findings for primary PNEN showed well-differentiated neuroendocrine neoplasms and R0 resection was successfully performed. The Ki-67 index increased with each resection in both cases. Both patients showed long-term survival (10 and 14 years, respectively). Repetitive lymphadenectomy for nodal recurrence of PNENs may improve patient prognosis. Oxford University Press 2021-10-13 /pmc/articles/PMC8515837/ /pubmed/34659739 http://dx.doi.org/10.1093/jscr/rjab446 Text en Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2021. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Series
Hane, Yuma
Tsuchikawa, Takahiro
Takeuchi, Satoshi
Tanaka, Kimitaka
Nakanishi, Yoshitsugu
Asano, Toshimichi
Noji, Takehiro
Kurashima, Yo
Ebihara, Yuma
Murakami, Soichi
Nakamura, Toru
Okamura, Keisuke
Shichinohe, Toshiaki
Hirano, Satoshi
Long-term survival after repetitive lymphadenectomy for nodal recurrence of pancreatic neuroendocrine neoplasms: a report of two cases
title Long-term survival after repetitive lymphadenectomy for nodal recurrence of pancreatic neuroendocrine neoplasms: a report of two cases
title_full Long-term survival after repetitive lymphadenectomy for nodal recurrence of pancreatic neuroendocrine neoplasms: a report of two cases
title_fullStr Long-term survival after repetitive lymphadenectomy for nodal recurrence of pancreatic neuroendocrine neoplasms: a report of two cases
title_full_unstemmed Long-term survival after repetitive lymphadenectomy for nodal recurrence of pancreatic neuroendocrine neoplasms: a report of two cases
title_short Long-term survival after repetitive lymphadenectomy for nodal recurrence of pancreatic neuroendocrine neoplasms: a report of two cases
title_sort long-term survival after repetitive lymphadenectomy for nodal recurrence of pancreatic neuroendocrine neoplasms: a report of two cases
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515837/
https://www.ncbi.nlm.nih.gov/pubmed/34659739
http://dx.doi.org/10.1093/jscr/rjab446
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