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2-Methoxyestradiol Ameliorates Angiotensin II–Induced Hypertension by Inhibiting Cytosolic Phospholipase A(2)α Activity in Female Mice

We tested the hypothesis that CYP1B1 (cytochrome P450 1B1)-17β-estradiol metabolite 2-methoxyestradiol protects against Ang II (angiotensin II)–induced hypertension by inhibiting group IV cPLA(2)α (cytosolic phospholipase A(2)α) activity and production of prohypertensive eicosanoids in female mice....

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Detalles Bibliográficos
Autores principales:	Song, Chi Young, Singh, Purnima, Motiwala, Mustafa, Shin, Ji Soo, Lew, Jessica, Dutta, Shubha R., Gonzalez, Frank J., Bonventre, Joseph V., Malik, Kafait U.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516072/ https://www.ncbi.nlm.nih.gov/pubmed/34628937 http://dx.doi.org/10.1161/HYPERTENSIONAHA.121.18181

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