Cargando…

Fucosyltransferase 2 inhibitors: Identification via docking and STD-NMR studies

Fucosyltransferase 2 (FUT2) catalyzes the biosynthesis of A, B, and H antigens and other important glycans, such as (Sialyl Lewis(x)) sLe(x), and (Sialyl Lewis(y)) sLe(y). The production of these glycans is increased in various cancers, hence to design and develop specific inhibitors of FUT2 is a th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zafar, Humaira, Atif, Muhammad, Atia-tul-Wahab, Choudhary, M. Iqbal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516197/ https://www.ncbi.nlm.nih.gov/pubmed/34648519 http://dx.doi.org/10.1371/journal.pone.0257623

Ejemplares similares

Identification of new inhibitors of NS5 from dengue virus using saturation transfer difference (STD-NMR) and molecular docking studies
por: Ullah, Asmat, et al.
Publicado: (2022)

Repurposing of US-FDA approved drugs against SARS-CoV-2 main protease (M(pro)) by using STD-NMR spectroscopy, in silico studies and antiviral assays
por: Khan, Abdul Mateen, et al.
Publicado: (2023)

In silico identification of potential inhibitors of key SARS-CoV-2 3CL hydrolase (Mpro) via molecular docking, MMGBSA predictive binding energy calculations, and molecular dynamics simulation
por: Choudhary, M. Iqbal, et al.
Publicado: (2020)

Antipsychotics drug aripiprazole as a lead against breast cancer cell line (MCF-7) in vitro
por: Badran, Adnan, et al.
Publicado: (2020)

Solvent-Dependent Structures of Natural Products Based on the Combined Use of DFT Calculations and (1)H-NMR Chemical Shifts
por: Mari, Saima H., et al.
Publicado: (2019)

2107. Anti-Biofilm Potential of Virulence Factor EsxB of Staphylococcus aureus against its own Sensitive Strain: Molecular Evidences
por: Ashraf, Faryal, et al.
Publicado: (2023)

A combined fragment-based virtual screening and STD-NMR approach for the identification of E-cadherin ligands
por: Vasile, Francesca, et al.
Publicado: (2022)

Binding modes of environmental endocrine disruptors to human serum albumin: insights from STD-NMR, ITC, spectroscopic and molecular docking studies
por: Yang, Hongqin, et al.
Publicado: (2017)

A STD-NMR Study of the Interaction of the Anabaena Ferredoxin-NADP(+) Reductase with the Coenzyme
por: Antonini, Lara V., et al.
Publicado: (2014)

Multifrequency STD NMR Unveils the Interactions of Antibiotics With Burkholderia multivorans Biofilm Exopolysaccharide
por: Nepravishta, Ridvan, et al.
Publicado: (2021)

Domain-specific interactions between MLN8237 and human serum albumin estimated by STD and WaterLOGSY NMR, ITC, spectroscopic, and docking techniques
por: Yang, Hongqin, et al.
Publicado: (2017)

Differential Epitope Mapping by STD NMR Spectroscopy To Reveal the Nature of Protein–Ligand Contacts
por: Monaco, Serena, et al.
Publicado: (2017)

Insights into the Interaction Mechanism of DTP3 with MKK7 by Using STD-NMR and Computational Approaches
por: Sandomenico, Annamaria, et al.
Publicado: (2020)

Seven new metabolites of drostanolone heptanoate by using Beauveria bassiana, and Macrophomina phaseolina cell suspension cultures
por: Hussain, Zahid, et al.
Publicado: (2020)

Imaging Saturation Transfer Difference (STD) NMR: Affinity and Specificity of Protein–Ligand Interactions from a Single NMR Sample
por: Monaco, Serena, et al.
Publicado: (2023)

Regulation of bistability in the std fimbrial operon of Salmonella enterica by DNA adenine methylation and transcription factors HdfR, StdE and StdF
por: García-Pastor, Lucía, et al.
Publicado: (2019)

Identification of a Sialosides binding pocket in early-lineage SARS-CoV-2 via an optimized STD NMR method: a novel explanation for coronavirus virulence and zoonosis
por: Chen, Geng, et al.
Publicado: (2022)

Bio-Catalytic Structural Transformation of Anti-cancer Steroid, Drostanolone Enanthate with Cephalosporium aphidicola and Fusarium lini, and Cytotoxic Potential Evaluation of Its Metabolites against Certain Cancer Cell Lines
por: Choudhary, M. Iqbal, et al.
Publicado: (2017)

Structural transformation of methasterone with Cunninghamella blakesleeana and Macrophomina phaseolina
por: Aamer, Muhammad, et al.
Publicado: (2022)

Exploration of ligand binding modes towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modelling approach
por: Vasile, Francesca, et al.
Publicado: (2018)

PG quiz: STD and pregnancy!
por: Baxi, Reema Rajesh, et al.
Publicado: (2017)

Whole-cell fungal-mediated structural transformation of anabolic drug metenolone acetate into potent anti-inflammatory metabolites
por: Siddiqui, Mahwish, et al.
Publicado: (2020)

Study of drug resistance-associated genetic mutations, and phylo-genetic analysis of HCV in the Province of Sindh, Pakistan
por: Faiz, Sirmast, et al.
Publicado: (2023)

Microbial transformation of anti-cancer steroid exemestane and cytotoxicity of its metabolites against cancer cell lines
por: Baydoun, Elias, et al.
Publicado: (2013)

Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor
por: Igonet, Sébastien, et al.
Publicado: (2018)

Molecular Recognition Patterns between Vitamin B12 and Proteins Explored through STD-NMR and In Silico Studies
por: Ghosh, Ruchira, et al.
Publicado: (2023)

New Anti-Inflammatory Metabolites by Microbial Transformation of Medrysone
por: Bano, Saira, et al.
Publicado: (2016)

Microbial transformation of mestanolone by Macrophomina phaseolina and Cunninghamella blakesleeana and anticancer activities of the transformed products
por: Farooq, Rabia, et al.
Publicado: (2018)

Inter-Ligand STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket
por: Monaco, Serena, et al.
Publicado: (2022)

STD Awareness Month — April 2013
Publicado: (2013)

STD Awareness Month — April 2014
Publicado: (2014)

Molecular docking simulation studies on potent butyrylcholinesterase inhibitors obtained from microbial transformation of dihydrotestosterone
por: Zafar, Salman, et al.
Publicado: (2013)

Cytotoxic Evaluation, Molecular Docking, and 2D-QSAR Studies of Dihydropyrimidinone Derivatives as Potential Anticancer Agents
por: Altaf, Reem, et al.
Publicado: (2022)

Improving STD testing behavior among high-risk young adults by offering STD testing at a vocational school
por: Spauwen, Laura WL, et al.
Publicado: (2011)

Deriving Ligand Orientation in Weak Protein–Ligand Complexes by DEEP‐STD NMR Spectroscopy in the Absence of Protein Chemical‐Shift Assignment
por: Nepravishta, Ridvan, et al.
Publicado: (2018)

STD patients’ preferences for HIV prevention strategies
por: Castro, Jose G, et al.
Publicado: (2014)

Biotransformation of a potent anabolic steroid, mibolerone, with Cunninghamella blakesleeana, C. echinulata, and Macrophomina phaseolina, and biological activity evaluation of its metabolites
por: Siddiqui, Mahwish, et al.
Publicado: (2017)

Structure and dynamics of the Arabidopsis O-fucosyltransferase SPINDLY
por: Kumar, Shivesh, et al.
Publicado: (2023)

Widespread Gene Conversion of Alpha-2-Fucosyltransferase Genes in Mammals
por: Abrantes, Joana, et al.
Publicado: (2009)

Clinical significance and biological function of fucosyltransferase 2 in lung adenocarcinoma
por: Zhou, Wenyuan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qemldf5976lnkf050tibmu9ncr