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Effect of chewing betel nut on the gut microbiota of Hainanese

Betel nut chewing (BNC) is prevalent in South Asia and Southeast Asia. BNC can affect host health by modulating the gut microbiota. The aim of this study is to evaluate the effect of BNC on the gut microbiota of the host. Feces samples were obtained from 34 BNC individuals from Ledong and Lingshui,...

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Detalles Bibliográficos
Autores principales: Ying, Li, Yang, Yunjia, Zhou, Jun, Huang, Hairong, Du, Guankui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516201/
https://www.ncbi.nlm.nih.gov/pubmed/34648581
http://dx.doi.org/10.1371/journal.pone.0258489
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author Ying, Li
Yang, Yunjia
Zhou, Jun
Huang, Hairong
Du, Guankui
author_facet Ying, Li
Yang, Yunjia
Zhou, Jun
Huang, Hairong
Du, Guankui
author_sort Ying, Li
collection PubMed
description Betel nut chewing (BNC) is prevalent in South Asia and Southeast Asia. BNC can affect host health by modulating the gut microbiota. The aim of this study is to evaluate the effect of BNC on the gut microbiota of the host. Feces samples were obtained from 34 BNC individuals from Ledong and Lingshui, Hainan, China. The microbiota was analyzed by 16S rRNA gene sequencing. BNC decreased the microbial α-diversity. Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria were the predominant phyla, accounting for 99.35% of the BNC group. The Firmicutes-to-Bacteroidetes ratio was significantly increased in the BNC group compared to a control group. The abundances of the families Aerococcaceae, Neisseriaceae, Moraxellaceae, Porphyromonadaceae, and Planococcaceae were decreased in the BNC/BNC_Male/BNC_Female groups compared to the control group, whereas the abundances of Coriobacteriaceae, Streptococcaceae, Micrococcaceae, Xanthomonadaceae, Coxiellaceae, Nocardioidaceae, Rhodobacteraceae, and Succinivibrionaceae were increased. In general, the gut microbiome profiles suggest that BNC may have positive effects, such as an increase in the abundance of beneficial microbes and a reduction in the abundance of disease-related microbes. However, BNC may also produce an increase in the abundance of disease-related microbes. Therefore, extraction of prebiotic components could increase the beneficial value of betel nut.
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spelling pubmed-85162012021-10-15 Effect of chewing betel nut on the gut microbiota of Hainanese Ying, Li Yang, Yunjia Zhou, Jun Huang, Hairong Du, Guankui PLoS One Research Article Betel nut chewing (BNC) is prevalent in South Asia and Southeast Asia. BNC can affect host health by modulating the gut microbiota. The aim of this study is to evaluate the effect of BNC on the gut microbiota of the host. Feces samples were obtained from 34 BNC individuals from Ledong and Lingshui, Hainan, China. The microbiota was analyzed by 16S rRNA gene sequencing. BNC decreased the microbial α-diversity. Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria were the predominant phyla, accounting for 99.35% of the BNC group. The Firmicutes-to-Bacteroidetes ratio was significantly increased in the BNC group compared to a control group. The abundances of the families Aerococcaceae, Neisseriaceae, Moraxellaceae, Porphyromonadaceae, and Planococcaceae were decreased in the BNC/BNC_Male/BNC_Female groups compared to the control group, whereas the abundances of Coriobacteriaceae, Streptococcaceae, Micrococcaceae, Xanthomonadaceae, Coxiellaceae, Nocardioidaceae, Rhodobacteraceae, and Succinivibrionaceae were increased. In general, the gut microbiome profiles suggest that BNC may have positive effects, such as an increase in the abundance of beneficial microbes and a reduction in the abundance of disease-related microbes. However, BNC may also produce an increase in the abundance of disease-related microbes. Therefore, extraction of prebiotic components could increase the beneficial value of betel nut. Public Library of Science 2021-10-14 /pmc/articles/PMC8516201/ /pubmed/34648581 http://dx.doi.org/10.1371/journal.pone.0258489 Text en © 2021 Ying et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ying, Li
Yang, Yunjia
Zhou, Jun
Huang, Hairong
Du, Guankui
Effect of chewing betel nut on the gut microbiota of Hainanese
title Effect of chewing betel nut on the gut microbiota of Hainanese
title_full Effect of chewing betel nut on the gut microbiota of Hainanese
title_fullStr Effect of chewing betel nut on the gut microbiota of Hainanese
title_full_unstemmed Effect of chewing betel nut on the gut microbiota of Hainanese
title_short Effect of chewing betel nut on the gut microbiota of Hainanese
title_sort effect of chewing betel nut on the gut microbiota of hainanese
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516201/
https://www.ncbi.nlm.nih.gov/pubmed/34648581
http://dx.doi.org/10.1371/journal.pone.0258489
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