Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial

Chronic infection with hepatitis B virus (HBV) leads to an increased risk of death from cirrhosis and hepatocellular carcinoma. Functional cure rates are low with current treatment options (nucleos(t)ide analogs (NAs) and pegylated interferons). Bepirovirsen is an antisense oligonucleotide targeting...

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Detalles Bibliográficos
Autores principales: Yuen, Man-Fung, Heo, Jeong, Jang, Jeong-Won, Yoon, Jung-Hwan, Kweon, Young-Oh, Park, Sung-Jae, Tami, Yvonne, You, Shihyun, Yates, Phillip, Tao, Yu, Cremer, Jennifer, Campbell, Fiona, Elston, Robert, Theodore, Dickens, Paff, Melanie, Bennett, C. Frank, Kwoh, T. Jesse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516644/
https://www.ncbi.nlm.nih.gov/pubmed/34642494
http://dx.doi.org/10.1038/s41591-021-01513-4

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