Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

Early increase of soluble urokinase plasminogen activator receptor (suPAR) serum levels is indicative of increased risk of progression of coronavirus disease 2019 (COVID-19) to respiratory failure. The SAVE-MORE double-blind, randomized controlled trial evaluated the efficacy and safety of anakinra,...

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Autores principales: Kyriazopoulou, Evdoxia, Poulakou, Garyfallia, Milionis, Haralampos, Metallidis, Simeon, Adamis, Georgios, Tsiakos, Konstantinos, Fragkou, Archontoula, Rapti, Aggeliki, Damoulari, Christina, Fantoni, Massimo, Kalomenidis, Ioannis, Chrysos, Georgios, Angheben, Andrea, Kainis, Ilias, Alexiou, Zoi, Castelli, Francesco, Serino, Francesco Saverio, Tsilika, Maria, Bakakos, Petros, Nicastri, Emanuele, Tzavara, Vassiliki, Kostis, Evangelos, Dagna, Lorenzo, Koufargyris, Panagiotis, Dimakou, Katerina, Savvanis, Spyridon, Tzatzagou, Glykeria, Chini, Maria, Cavalli, Giulio, Bassetti, Matteo, Katrini, Konstantina, Kotsis, Vasileios, Tsoukalas, George, Selmi, Carlo, Bliziotis, Ioannis, Samarkos, Michael, Doumas, Michael, Ktena, Sofia, Masgala, Aikaterini, Papanikolaou, Ilias, Kosmidou, Maria, Myrodia, Dimitra-Melia, Argyraki, Aikaterini, Cardellino, Chiara Simona, Koliakou, Katerina, Katsigianni, Eleni-Ioanna, Rapti, Vassiliki, Giannitsioti, Efthymia, Cingolani, Antonella, Micha, Styliani, Akinosoglou, Karolina, Liatsis-Douvitsas, Orestis, Symbardi, Styliani, Gatselis, Nikolaos, Mouktaroudi, Maria, Ippolito, Giuseppe, Florou, Eleni, Kotsaki, Antigone, Netea, Mihai G., Eugen-Olsen, Jesper, Kyprianou, Miltiades, Panagopoulos, Periklis, Dalekos, George N., Giamarellos-Bourboulis, Evangelos J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516650/
https://www.ncbi.nlm.nih.gov/pubmed/34480127
http://dx.doi.org/10.1038/s41591-021-01499-z

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