Randomized Clinical Trial Investigating the Effect of Consistent, Developmentally-appropriate, and Evidence-based Multi-sensory Exposures in the NICU

OBJECTIVE: Evaluate the effect of a manualized multisensory program, applied across NICU hospitalization, on infant and parent outcomes. STUDY DESIGN: Seventy parent-infant dyads (born ≤ 32 weeks gestation) in a Level IV NICU were randomized at birth to the multisensory program or standard-of-care. Parents in the multisensory group administered prespecified amounts of age-appropriate, evidence-based sensory interventions to their infants each day during NICU hospitalization according to the Supporting and Enhancing NICU Sensory Experiences (SENSE) program. RESULTS: Infants who received the SENSE program had more lethargy on the NICU Network Neurobehavioral Scale (NNNS) (p=0.05), even after controlling for medical and social risk (p=0.043), and had higher Communication scores on the Ages and Stages Questionnaire (p=0.04) at one-year corrected age, but this relationship failed to reach significance after controlling for medical and social risk (p=0.12). CONCLUSION: The SENSE program shows promise for improving outcomes, but more research with larger sample sizes is needed.