RNA sequencing and functional studies of patient-derived cells reveal that neurexin-1 and regulators of this pathway are associated with poor outcomes in Ewing sarcoma

PURPOSE: The development of biomarkers and molecularly targeted therapies for patients with Ewing sarcoma (ES) in order to minimise morbidity and improve outcome is urgently needed. Here, we set out to isolate and characterise patient-derived ES primary cell cultures and daughter cancer stem-like ce...

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Detalles Bibliográficos
Autores principales: Roundhill, Elizabeth Ann, Chicon-Bosch, Mariona, Jeys, Lee, Parry, Michael, Rankin, Kenneth S, Droop, Alastair, Burchill, Susan Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516792/
https://www.ncbi.nlm.nih.gov/pubmed/34403115
http://dx.doi.org/10.1007/s13402-021-00619-8

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