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Relationship between stereopsis and vision-related quality of life following intravitreal ranibizumab injections for central retinal vein occlusion
The study aimed to evaluate changes in stereopsis and vision-related quality of life (VR-QOL) in patients with central retinal vein occlusion (CRVO) following intravitreal ranibizumab injection (IVR) and investigate the relationship between stereopsis and VR-QOL. This study included 23 treatment-naï...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516903/ https://www.ncbi.nlm.nih.gov/pubmed/34650099 http://dx.doi.org/10.1038/s41598-021-00094-z |
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author | Okamoto, Fumiki Tomioka, Mizuki Murakami, Tomoya Morikawa, Shohei Sugiura, Yoshimi Hiraoka, Takahiro Oshika, Tetsuro |
author_facet | Okamoto, Fumiki Tomioka, Mizuki Murakami, Tomoya Morikawa, Shohei Sugiura, Yoshimi Hiraoka, Takahiro Oshika, Tetsuro |
author_sort | Okamoto, Fumiki |
collection | PubMed |
description | The study aimed to evaluate changes in stereopsis and vision-related quality of life (VR-QOL) in patients with central retinal vein occlusion (CRVO) following intravitreal ranibizumab injection (IVR) and investigate the relationship between stereopsis and VR-QOL. This study included 23 treatment-naïve patients with non-ischemic CRVO and 13 age-matched normal controls. Stereopsis, best-corrected visual acuity (BCVA), VR-QOL, and retinal microstructures were examined pre-treatment and 12 months post-treatment. The Titmus Stereo Test (TST) and TNO stereotest (TNO) were used to evaluate stereopsis. VR-QOL was evaluated using the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25). IVR immediately and significantly improved the TST values, TNO values, composite VFQ-25 score, BCVA, and central foveal thickness in patients with CRVO. The 12-month post-treatment TST and TNO values were significantly worse in the CRVO group compared to those in the normal group. At the baseline, the composite VFQ-25 score significantly correlated only with the TST value. Multivariate analysis revealed significant associations between the 12-month post-treatment composite VFQ-25 score and the baseline and 12-month post-treatment TNO values. In conclusion, IVR immediately improved stereopsis in CRVO, albeit below normal levels. Stereopsis (not visual acuity) was associated with pre- and post-treatment VR-QOL in patients with CRVO. |
format | Online Article Text |
id | pubmed-8516903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-85169032021-10-15 Relationship between stereopsis and vision-related quality of life following intravitreal ranibizumab injections for central retinal vein occlusion Okamoto, Fumiki Tomioka, Mizuki Murakami, Tomoya Morikawa, Shohei Sugiura, Yoshimi Hiraoka, Takahiro Oshika, Tetsuro Sci Rep Article The study aimed to evaluate changes in stereopsis and vision-related quality of life (VR-QOL) in patients with central retinal vein occlusion (CRVO) following intravitreal ranibizumab injection (IVR) and investigate the relationship between stereopsis and VR-QOL. This study included 23 treatment-naïve patients with non-ischemic CRVO and 13 age-matched normal controls. Stereopsis, best-corrected visual acuity (BCVA), VR-QOL, and retinal microstructures were examined pre-treatment and 12 months post-treatment. The Titmus Stereo Test (TST) and TNO stereotest (TNO) were used to evaluate stereopsis. VR-QOL was evaluated using the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25). IVR immediately and significantly improved the TST values, TNO values, composite VFQ-25 score, BCVA, and central foveal thickness in patients with CRVO. The 12-month post-treatment TST and TNO values were significantly worse in the CRVO group compared to those in the normal group. At the baseline, the composite VFQ-25 score significantly correlated only with the TST value. Multivariate analysis revealed significant associations between the 12-month post-treatment composite VFQ-25 score and the baseline and 12-month post-treatment TNO values. In conclusion, IVR immediately improved stereopsis in CRVO, albeit below normal levels. Stereopsis (not visual acuity) was associated with pre- and post-treatment VR-QOL in patients with CRVO. Nature Publishing Group UK 2021-10-14 /pmc/articles/PMC8516903/ /pubmed/34650099 http://dx.doi.org/10.1038/s41598-021-00094-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Okamoto, Fumiki Tomioka, Mizuki Murakami, Tomoya Morikawa, Shohei Sugiura, Yoshimi Hiraoka, Takahiro Oshika, Tetsuro Relationship between stereopsis and vision-related quality of life following intravitreal ranibizumab injections for central retinal vein occlusion |
title | Relationship between stereopsis and vision-related quality of life following intravitreal ranibizumab injections for central retinal vein occlusion |
title_full | Relationship between stereopsis and vision-related quality of life following intravitreal ranibizumab injections for central retinal vein occlusion |
title_fullStr | Relationship between stereopsis and vision-related quality of life following intravitreal ranibizumab injections for central retinal vein occlusion |
title_full_unstemmed | Relationship between stereopsis and vision-related quality of life following intravitreal ranibizumab injections for central retinal vein occlusion |
title_short | Relationship between stereopsis and vision-related quality of life following intravitreal ranibizumab injections for central retinal vein occlusion |
title_sort | relationship between stereopsis and vision-related quality of life following intravitreal ranibizumab injections for central retinal vein occlusion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516903/ https://www.ncbi.nlm.nih.gov/pubmed/34650099 http://dx.doi.org/10.1038/s41598-021-00094-z |
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