Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation

Endogenous retroviruses (ERVs) comprise a significant portion of mammalian genomes. Although specific ERV loci feature regulatory roles for host gene expression, most ERV integrations are transcriptionally repressed by Setdb1-mediated H3K9me3 and DNA methylation. However, the protein network which r...

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Detalles Bibliográficos
Autores principales: Groh, Sophia, Milton, Anna Viktoria, Marinelli, Lisa Katherina, Sickinger, Cara V., Russo, Angela, Bollig, Heike, de Almeida, Gustavo Pereira, Schmidt, Andreas, Forné, Ignasi, Imhof, Axel, Schotta, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516933/
https://www.ncbi.nlm.nih.gov/pubmed/34650047
http://dx.doi.org/10.1038/s41467-021-26288-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516933/
https://www.ncbi.nlm.nih.gov/pubmed/34650047
http://dx.doi.org/10.1038/s41467-021-26288-7

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