Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73

The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By comparing their function, phenotype and transcriptomic profi...

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Detalles Bibliográficos
Autores principales: Jarvis, Lorna B., Rainbow, Daniel B., Coppard, Valerie, Howlett, Sarah K., Georgieva, Zoya, Davies, Jessica L., Mullay, Harpreet Kaur, Hester, Joanna, Ashmore, Tom, Van Den Bosch, Aletta, Grist, James T., Coles, Alasdair J., Mousa, Hani S., Pluchino, Stefano, Mahbubani, Krishnaa T., Griffin, Julian L., Saeb-Parsy, Kourosh, Issa, Fadi, Peruzzotti-Jametti, Luca, Wicker, Linda S., Jones, Joanne L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516976/
https://www.ncbi.nlm.nih.gov/pubmed/34650224
http://dx.doi.org/10.1038/s42003-021-02721-x

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