The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends

Molecular chaperones contribute to the maintenance of cellular protein homoeostasis through assisting de novo protein folding and preventing amyloid formation. Chaperones of the Hsp70 family can further disaggregate otherwise irreversible aggregate species such as α-synuclein fibrils, which accumula...

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Detalles Bibliográficos
Autores principales: Schneider, Matthias M., Gautam, Saurabh, Herling, Therese W., Andrzejewska, Ewa, Krainer, Georg, Miller, Alyssa M., Trinkaus, Victoria A., Peter, Quentin A. E., Ruggeri, Francesco Simone, Vendruscolo, Michele, Bracher, Andreas, Dobson, Christopher M., Hartl, F. Ulrich, Knowles, Tuomas P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516981/
https://www.ncbi.nlm.nih.gov/pubmed/34650037
http://dx.doi.org/10.1038/s41467-021-25966-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516981/
https://www.ncbi.nlm.nih.gov/pubmed/34650037
http://dx.doi.org/10.1038/s41467-021-25966-w

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