Engineered mesenchymal stromal cell therapy during human lung ex vivo lung perfusion is compromised by acidic lung microenvironment

Ex vivo lung perfusion (EVLP) is an excellent platform to apply novel therapeutics, such as gene and cell therapies, before lung transplantation. We investigated the concept of human donor lung engineering during EVLP by combining gene and cell therapies. Premodified cryopreserved mesenchymal stroma...

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Detalles Bibliográficos
Autores principales: Nykänen, Antti I., Mariscal, Andrea, Duong, Allen, Estrada, Catalina, Ali, Aadil, Hough, Olivia, Sage, Andrew, Chao, Bonnie T., Chen, Manyin, Gokhale, Hemant, Shan, Hongchao, Bai, Xiaohui, Zehong, Guan, Yeung, Jonathan, Waddell, Tom, Martinu, Tereza, Juvet, Stephen, Cypel, Marcelo, Liu, Mingyao, Davies, John E., Keshavjee, Shaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516994/
https://www.ncbi.nlm.nih.gov/pubmed/34703841
http://dx.doi.org/10.1016/j.omtm.2021.05.018

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