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Novel two-chain structure utilizing KIRS2/DAP12 domain improves the safety and efficacy of CAR-T cells in adults with r/r B-ALL

Engineered T cells that express chimeric antigen receptors (CARs) have been a promising therapy for hematologic malignancies. The optimization of CAR structure using different signaling domains can alter a wide range of CAR-T cell properties, including anti-tumor activity, long-term persistence, and...

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Detalles Bibliográficos
Autores principales:	Sun, Ming, Xu, Peipei, Wang, Enxiu, Zhou, Min, Xu, Tongpeng, Wang, Jing, Wang, Qian, Wang, Bo, Lu, Kaihua, Wang, Chen, Chen, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517091/ https://www.ncbi.nlm.nih.gov/pubmed/34703879 http://dx.doi.org/10.1016/j.omto.2021.08.014

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