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Resurgent Sodium Current in Neurons of the Cerebral Cortex
In the late ’90, Dr. Indira Raman, at the time a postdoctoral fellow with Dr. Bruce Bean, at Harvard University, identified a new type of sodium current, flowing through the channels that reopens when the membrane is repolarized. This current, called “resurgent Sodium current,” was originally identi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517112/ https://www.ncbi.nlm.nih.gov/pubmed/34658797 http://dx.doi.org/10.3389/fncel.2021.760610 |
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author | Quattrocolo, Giulia Dunville, Keagan Nigro, Maximiliano José |
author_facet | Quattrocolo, Giulia Dunville, Keagan Nigro, Maximiliano José |
author_sort | Quattrocolo, Giulia |
collection | PubMed |
description | In the late ’90, Dr. Indira Raman, at the time a postdoctoral fellow with Dr. Bruce Bean, at Harvard University, identified a new type of sodium current, flowing through the channels that reopens when the membrane is repolarized. This current, called “resurgent Sodium current,” was originally identified in cerebellar Purkinje neurons and has now been confirmed in around 20 different neuronal types. Since moving to Northwestern University in 1999 to establish her own research group, Dr. Raman has dedicated great efforts in identifying the mechanisms supporting the resurgent Sodium current and how its biophysical properties shape the firing of the different cell types. Her work has impacted greatly the field of cellular neurophysiology, from basic research to translation neuroscience. In fact, alterations in the resurgent sodium currents have been observed in several neuropathologies, from Huntington’s disease to epilepsy. In this Perspective we will focus on the current knowledge on the expression and function of the resurgent Sodium current in neurons of the cerebral cortex and hippocampus. We will also briefly highlight the role of Dr. Raman’s as teacher and mentor, not only for her pupils, but for the whole scientific community. |
format | Online Article Text |
id | pubmed-8517112 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85171122021-10-16 Resurgent Sodium Current in Neurons of the Cerebral Cortex Quattrocolo, Giulia Dunville, Keagan Nigro, Maximiliano José Front Cell Neurosci Neuroscience In the late ’90, Dr. Indira Raman, at the time a postdoctoral fellow with Dr. Bruce Bean, at Harvard University, identified a new type of sodium current, flowing through the channels that reopens when the membrane is repolarized. This current, called “resurgent Sodium current,” was originally identified in cerebellar Purkinje neurons and has now been confirmed in around 20 different neuronal types. Since moving to Northwestern University in 1999 to establish her own research group, Dr. Raman has dedicated great efforts in identifying the mechanisms supporting the resurgent Sodium current and how its biophysical properties shape the firing of the different cell types. Her work has impacted greatly the field of cellular neurophysiology, from basic research to translation neuroscience. In fact, alterations in the resurgent sodium currents have been observed in several neuropathologies, from Huntington’s disease to epilepsy. In this Perspective we will focus on the current knowledge on the expression and function of the resurgent Sodium current in neurons of the cerebral cortex and hippocampus. We will also briefly highlight the role of Dr. Raman’s as teacher and mentor, not only for her pupils, but for the whole scientific community. Frontiers Media S.A. 2021-10-01 /pmc/articles/PMC8517112/ /pubmed/34658797 http://dx.doi.org/10.3389/fncel.2021.760610 Text en Copyright © 2021 Quattrocolo, Dunville and Nigro. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Quattrocolo, Giulia Dunville, Keagan Nigro, Maximiliano José Resurgent Sodium Current in Neurons of the Cerebral Cortex |
title | Resurgent Sodium Current in Neurons of the Cerebral Cortex |
title_full | Resurgent Sodium Current in Neurons of the Cerebral Cortex |
title_fullStr | Resurgent Sodium Current in Neurons of the Cerebral Cortex |
title_full_unstemmed | Resurgent Sodium Current in Neurons of the Cerebral Cortex |
title_short | Resurgent Sodium Current in Neurons of the Cerebral Cortex |
title_sort | resurgent sodium current in neurons of the cerebral cortex |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517112/ https://www.ncbi.nlm.nih.gov/pubmed/34658797 http://dx.doi.org/10.3389/fncel.2021.760610 |
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