Facile synthesis and in vitro anticancer evaluation of a new series of tetrahydroquinoline

Tetrahydroquinoline (THQ) is an important structure for synthesizing multiple biologically active derivatives. Thus, we developed new quinoline derivatives and investigated them as anticancer agents. First, infrared spectroscopy, nuclear magnetic resonance spectroscopy, and other techniques were use...

Descripción completa

Detalles Bibliográficos
Autores principales: Fathy, Usama, Abd El Salam, Hayam A., Fayed, Eman A., Elgamal, Abdelbaset M., Gouda, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517157/
https://www.ncbi.nlm.nih.gov/pubmed/34693052
http://dx.doi.org/10.1016/j.heliyon.2021.e08117
Descripción
Sumario:Tetrahydroquinoline (THQ) is an important structure for synthesizing multiple biologically active derivatives. Thus, we developed new quinoline derivatives and investigated them as anticancer agents. First, infrared spectroscopy, nuclear magnetic resonance spectroscopy, and other techniques were used to confirm the structure of synthesized compounds. Then, they were assessed in vitro against three human cancer cell lines. Consequently, four compounds, 10, 13, 15, and 16, were identified as promising anticancer agents with pyrazolo quinoline derivative (15) exhibiting the highest potential IC(50) and a strong apoptotic effect on three cell lines.

Ejemplares similares