Facile synthesis and in vitro anticancer evaluation of a new series of tetrahydroquinoline

Tetrahydroquinoline (THQ) is an important structure for synthesizing multiple biologically active derivatives. Thus, we developed new quinoline derivatives and investigated them as anticancer agents. First, infrared spectroscopy, nuclear magnetic resonance spectroscopy, and other techniques were use...

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Detalles Bibliográficos
Autores principales: Fathy, Usama, Abd El Salam, Hayam A., Fayed, Eman A., Elgamal, Abdelbaset M., Gouda, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517157/
https://www.ncbi.nlm.nih.gov/pubmed/34693052
http://dx.doi.org/10.1016/j.heliyon.2021.e08117
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author Fathy, Usama
Abd El Salam, Hayam A.
Fayed, Eman A.
Elgamal, Abdelbaset M.
Gouda, Ahmed
author_facet Fathy, Usama
Abd El Salam, Hayam A.
Fayed, Eman A.
Elgamal, Abdelbaset M.
Gouda, Ahmed
author_sort Fathy, Usama
collection PubMed
description Tetrahydroquinoline (THQ) is an important structure for synthesizing multiple biologically active derivatives. Thus, we developed new quinoline derivatives and investigated them as anticancer agents. First, infrared spectroscopy, nuclear magnetic resonance spectroscopy, and other techniques were used to confirm the structure of synthesized compounds. Then, they were assessed in vitro against three human cancer cell lines. Consequently, four compounds, 10, 13, 15, and 16, were identified as promising anticancer agents with pyrazolo quinoline derivative (15) exhibiting the highest potential IC(50) and a strong apoptotic effect on three cell lines.
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spelling pubmed-85171572021-10-21 Facile synthesis and in vitro anticancer evaluation of a new series of tetrahydroquinoline Fathy, Usama Abd El Salam, Hayam A. Fayed, Eman A. Elgamal, Abdelbaset M. Gouda, Ahmed Heliyon Research Article Tetrahydroquinoline (THQ) is an important structure for synthesizing multiple biologically active derivatives. Thus, we developed new quinoline derivatives and investigated them as anticancer agents. First, infrared spectroscopy, nuclear magnetic resonance spectroscopy, and other techniques were used to confirm the structure of synthesized compounds. Then, they were assessed in vitro against three human cancer cell lines. Consequently, four compounds, 10, 13, 15, and 16, were identified as promising anticancer agents with pyrazolo quinoline derivative (15) exhibiting the highest potential IC(50) and a strong apoptotic effect on three cell lines. Elsevier 2021-10-04 /pmc/articles/PMC8517157/ /pubmed/34693052 http://dx.doi.org/10.1016/j.heliyon.2021.e08117 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Fathy, Usama
Abd El Salam, Hayam A.
Fayed, Eman A.
Elgamal, Abdelbaset M.
Gouda, Ahmed
Facile synthesis and in vitro anticancer evaluation of a new series of tetrahydroquinoline
title Facile synthesis and in vitro anticancer evaluation of a new series of tetrahydroquinoline
title_full Facile synthesis and in vitro anticancer evaluation of a new series of tetrahydroquinoline
title_fullStr Facile synthesis and in vitro anticancer evaluation of a new series of tetrahydroquinoline
title_full_unstemmed Facile synthesis and in vitro anticancer evaluation of a new series of tetrahydroquinoline
title_short Facile synthesis and in vitro anticancer evaluation of a new series of tetrahydroquinoline
title_sort facile synthesis and in vitro anticancer evaluation of a new series of tetrahydroquinoline
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517157/
https://www.ncbi.nlm.nih.gov/pubmed/34693052
http://dx.doi.org/10.1016/j.heliyon.2021.e08117
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