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A Conserved Structural Role for the Walker-A Lysine in P-Loop Containing Kinases

Bacterial tyrosine kinases (BY-kinases) and shikimate kinases (SKs) comprise two structurally divergent P-loop containing enzyme families that share similar catalytic site geometries, most notably with respect to their Walker-A, Walker-B, and DxD motifs. We had previously demonstrated that in BY-kin...

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Detalles Bibliográficos
Autores principales: Hajredini, Fatlum, Ghose, Ranajeet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517177/
https://www.ncbi.nlm.nih.gov/pubmed/34660698
http://dx.doi.org/10.3389/fmolb.2021.747206

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