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Association of Serum Uric Acid Levels in Meige’s Syndrome

Uric acid (URIC) is a natural antioxidant, and it has been shown that low levels of URIC could be a risk factor for the development of Parkinson’s disease. Our aim was to investigate whether URIC also plays a role in Meige’s syndrome (MS). We conducted a cohort study to compare serum URIC levels bet...

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Autores principales: Guan, Haochen, Geng, Zhi, Yuan, Weijie, Chang, Bowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517269/
https://www.ncbi.nlm.nih.gov/pubmed/34658782
http://dx.doi.org/10.3389/fnins.2021.755056
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author Guan, Haochen
Geng, Zhi
Yuan, Weijie
Chang, Bowen
author_facet Guan, Haochen
Geng, Zhi
Yuan, Weijie
Chang, Bowen
author_sort Guan, Haochen
collection PubMed
description Uric acid (URIC) is a natural antioxidant, and it has been shown that low levels of URIC could be a risk factor for the development of Parkinson’s disease. Our aim was to investigate whether URIC also plays a role in Meige’s syndrome (MS). We conducted a cohort study to compare serum URIC levels between patients with MS and healthy controls. In addition, we analyzed the impact of URIC on the risk of MS and symptom severity. Compared with normal subjects, URIC content was remarkably decreased in MS patients. In addition, URIC was regarded as a protective factor for MS, as verified by multivariate logistic regression models. We also found non-linear relationships between the levels of serum URIC and the incidence rate of MS and the Burke-Fahn-Marsden dystonia rating scale score. Our study is the first to show a connection between serum URIC levels and MS. Low serum URIC levels indicate an increased risk of MS incidence and more severe clinical symptoms. Our findings provide new insights into the prevention and treatment of MS.
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spelling pubmed-85172692021-10-16 Association of Serum Uric Acid Levels in Meige’s Syndrome Guan, Haochen Geng, Zhi Yuan, Weijie Chang, Bowen Front Neurosci Neuroscience Uric acid (URIC) is a natural antioxidant, and it has been shown that low levels of URIC could be a risk factor for the development of Parkinson’s disease. Our aim was to investigate whether URIC also plays a role in Meige’s syndrome (MS). We conducted a cohort study to compare serum URIC levels between patients with MS and healthy controls. In addition, we analyzed the impact of URIC on the risk of MS and symptom severity. Compared with normal subjects, URIC content was remarkably decreased in MS patients. In addition, URIC was regarded as a protective factor for MS, as verified by multivariate logistic regression models. We also found non-linear relationships between the levels of serum URIC and the incidence rate of MS and the Burke-Fahn-Marsden dystonia rating scale score. Our study is the first to show a connection between serum URIC levels and MS. Low serum URIC levels indicate an increased risk of MS incidence and more severe clinical symptoms. Our findings provide new insights into the prevention and treatment of MS. Frontiers Media S.A. 2021-10-01 /pmc/articles/PMC8517269/ /pubmed/34658782 http://dx.doi.org/10.3389/fnins.2021.755056 Text en Copyright © 2021 Guan, Geng, Yuan and Chang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Guan, Haochen
Geng, Zhi
Yuan, Weijie
Chang, Bowen
Association of Serum Uric Acid Levels in Meige’s Syndrome
title Association of Serum Uric Acid Levels in Meige’s Syndrome
title_full Association of Serum Uric Acid Levels in Meige’s Syndrome
title_fullStr Association of Serum Uric Acid Levels in Meige’s Syndrome
title_full_unstemmed Association of Serum Uric Acid Levels in Meige’s Syndrome
title_short Association of Serum Uric Acid Levels in Meige’s Syndrome
title_sort association of serum uric acid levels in meige’s syndrome
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517269/
https://www.ncbi.nlm.nih.gov/pubmed/34658782
http://dx.doi.org/10.3389/fnins.2021.755056
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