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Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development

Developmental programming is carried out by a sequence of molecular choices that epigenetically mark the genome to generate the stable cell types which make up the total organism. A number of important processes, such as genomic imprinting, selection of immune or olfactory receptors, and X-chromosom...

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Detalles Bibliográficos
Autores principales: Bergman, Yehudit, Simon, Itamar, Cedar, Howard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517340/
https://www.ncbi.nlm.nih.gov/pubmed/34660595
http://dx.doi.org/10.3389/fcell.2021.737681
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author Bergman, Yehudit
Simon, Itamar
Cedar, Howard
author_facet Bergman, Yehudit
Simon, Itamar
Cedar, Howard
author_sort Bergman, Yehudit
collection PubMed
description Developmental programming is carried out by a sequence of molecular choices that epigenetically mark the genome to generate the stable cell types which make up the total organism. A number of important processes, such as genomic imprinting, selection of immune or olfactory receptors, and X-chromosome inactivation in females are dependent on the ability to stably choose one single allele in each cell. In this perspective, we propose that asynchronous replication timing (ASRT) serves as the basis for a sophisticated universal mechanism for mediating and maintaining these decisions.
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spelling pubmed-85173402021-10-16 Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development Bergman, Yehudit Simon, Itamar Cedar, Howard Front Cell Dev Biol Cell and Developmental Biology Developmental programming is carried out by a sequence of molecular choices that epigenetically mark the genome to generate the stable cell types which make up the total organism. A number of important processes, such as genomic imprinting, selection of immune or olfactory receptors, and X-chromosome inactivation in females are dependent on the ability to stably choose one single allele in each cell. In this perspective, we propose that asynchronous replication timing (ASRT) serves as the basis for a sophisticated universal mechanism for mediating and maintaining these decisions. Frontiers Media S.A. 2021-10-01 /pmc/articles/PMC8517340/ /pubmed/34660595 http://dx.doi.org/10.3389/fcell.2021.737681 Text en Copyright © 2021 Bergman, Simon and Cedar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Bergman, Yehudit
Simon, Itamar
Cedar, Howard
Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development
title Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development
title_full Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development
title_fullStr Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development
title_full_unstemmed Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development
title_short Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development
title_sort asynchronous replication timing: a mechanism for monoallelic choice during development
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517340/
https://www.ncbi.nlm.nih.gov/pubmed/34660595
http://dx.doi.org/10.3389/fcell.2021.737681
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