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Serum Oxytocin Level Correlates With Gut Microbiome Dysbiosis in Children With Autism Spectrum Disorder

To investigate the levels of serum oxytocin (OT) in children with autism spectrum disorder (ASD) and explore the association between OT levels and gut microbiota relative abundances, we recruited 39 children with ASD children–mother dyads and 44 healthy controls. Serum OT levels were determined via...

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Autores principales: Huang, Minshi, Liu, Kevin, Wei, Zhen, Feng, Zhe, Chen, Jierong, Yang, Jie, Zhong, Qin, Wan, Guobin, Kong, Xue-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517432/
https://www.ncbi.nlm.nih.gov/pubmed/34658767
http://dx.doi.org/10.3389/fnins.2021.721884
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author Huang, Minshi
Liu, Kevin
Wei, Zhen
Feng, Zhe
Chen, Jierong
Yang, Jie
Zhong, Qin
Wan, Guobin
Kong, Xue-Jun
author_facet Huang, Minshi
Liu, Kevin
Wei, Zhen
Feng, Zhe
Chen, Jierong
Yang, Jie
Zhong, Qin
Wan, Guobin
Kong, Xue-Jun
author_sort Huang, Minshi
collection PubMed
description To investigate the levels of serum oxytocin (OT) in children with autism spectrum disorder (ASD) and explore the association between OT levels and gut microbiota relative abundances, we recruited 39 children with ASD children–mother dyads and 44 healthy controls. Serum OT levels were determined via enzyme-linked immunosorbent assay and gut microbiota abundances were determined by 16S rRNA sequencing. We found that the OT level of ASD was lower than the healthy control group overall (P < 0.05). Furthermore, we present preliminary evidence of gut microbiome dysbiosis observed among children with ASD to lower levels of OT based on correlational analysis between serum OT and specific gut microbiota abundances (P < 0.05). We also found sex-related differences in serum OT levels and GIS index (P < 0.05). However, the generalizability of findings relevant to females with ASD require further validation in future studies involving larger sample sizes and balanced sex distributions due to the small number of females involved in this study. Nonetheless, these new findings further our understanding of the effects of low serum OT levels among individuals with ASD, which provides preliminary evidence in hopes of guiding future study design or mechanistic studies. The findings of the present study may be suggestive of potential ASD subtypes based on ASD severity and gut microbiome composition that may facilitate the prediction of the therapeutic responses of OT among those with ASD.
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spelling pubmed-85174322021-10-16 Serum Oxytocin Level Correlates With Gut Microbiome Dysbiosis in Children With Autism Spectrum Disorder Huang, Minshi Liu, Kevin Wei, Zhen Feng, Zhe Chen, Jierong Yang, Jie Zhong, Qin Wan, Guobin Kong, Xue-Jun Front Neurosci Neuroscience To investigate the levels of serum oxytocin (OT) in children with autism spectrum disorder (ASD) and explore the association between OT levels and gut microbiota relative abundances, we recruited 39 children with ASD children–mother dyads and 44 healthy controls. Serum OT levels were determined via enzyme-linked immunosorbent assay and gut microbiota abundances were determined by 16S rRNA sequencing. We found that the OT level of ASD was lower than the healthy control group overall (P < 0.05). Furthermore, we present preliminary evidence of gut microbiome dysbiosis observed among children with ASD to lower levels of OT based on correlational analysis between serum OT and specific gut microbiota abundances (P < 0.05). We also found sex-related differences in serum OT levels and GIS index (P < 0.05). However, the generalizability of findings relevant to females with ASD require further validation in future studies involving larger sample sizes and balanced sex distributions due to the small number of females involved in this study. Nonetheless, these new findings further our understanding of the effects of low serum OT levels among individuals with ASD, which provides preliminary evidence in hopes of guiding future study design or mechanistic studies. The findings of the present study may be suggestive of potential ASD subtypes based on ASD severity and gut microbiome composition that may facilitate the prediction of the therapeutic responses of OT among those with ASD. Frontiers Media S.A. 2021-10-01 /pmc/articles/PMC8517432/ /pubmed/34658767 http://dx.doi.org/10.3389/fnins.2021.721884 Text en Copyright © 2021 Huang, Liu, Wei, Feng, Chen, Yang, Zhong, Wan and Kong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Huang, Minshi
Liu, Kevin
Wei, Zhen
Feng, Zhe
Chen, Jierong
Yang, Jie
Zhong, Qin
Wan, Guobin
Kong, Xue-Jun
Serum Oxytocin Level Correlates With Gut Microbiome Dysbiosis in Children With Autism Spectrum Disorder
title Serum Oxytocin Level Correlates With Gut Microbiome Dysbiosis in Children With Autism Spectrum Disorder
title_full Serum Oxytocin Level Correlates With Gut Microbiome Dysbiosis in Children With Autism Spectrum Disorder
title_fullStr Serum Oxytocin Level Correlates With Gut Microbiome Dysbiosis in Children With Autism Spectrum Disorder
title_full_unstemmed Serum Oxytocin Level Correlates With Gut Microbiome Dysbiosis in Children With Autism Spectrum Disorder
title_short Serum Oxytocin Level Correlates With Gut Microbiome Dysbiosis in Children With Autism Spectrum Disorder
title_sort serum oxytocin level correlates with gut microbiome dysbiosis in children with autism spectrum disorder
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517432/
https://www.ncbi.nlm.nih.gov/pubmed/34658767
http://dx.doi.org/10.3389/fnins.2021.721884
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