Cargando…

Demographic and Clinical Features of Small-for-Gestational-Age Infants Born to Mothers With Gestational Diabetes Mellitus

We studied the demographic and clinical characteristic, risk factors, outcomes of full-term small-for-gestational-age (SGA) infants born to mothers with gestational diabetes mellitus (GDM) in China. A retrospective case-control study that included 1981 SGA infants was conducted; the demographic and...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Juncao, Xiao, Huimin, Yang, Yong, Tang, Yaping, Yang, Xiaoqi, Zhang, Zhe, Lu, Weineng, Yao, Jie, Huang, Longguang, Liu, Xiaoping, Zhou, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517473/
https://www.ncbi.nlm.nih.gov/pubmed/34660493
http://dx.doi.org/10.3389/fped.2021.741793
_version_ 1784584026320797696
author Chen, Juncao
Xiao, Huimin
Yang, Yong
Tang, Yaping
Yang, Xiaoqi
Zhang, Zhe
Lu, Weineng
Yao, Jie
Huang, Longguang
Liu, Xiaoping
Zhou, Wei
author_facet Chen, Juncao
Xiao, Huimin
Yang, Yong
Tang, Yaping
Yang, Xiaoqi
Zhang, Zhe
Lu, Weineng
Yao, Jie
Huang, Longguang
Liu, Xiaoping
Zhou, Wei
author_sort Chen, Juncao
collection PubMed
description We studied the demographic and clinical characteristic, risk factors, outcomes of full-term small-for-gestational-age (SGA) infants born to mothers with gestational diabetes mellitus (GDM) in China. A retrospective case-control study that included 1981 SGA infants was conducted; the demographic and clinical data between SGA infants born to mothers with and without GDM were compared. Of 383 SGA infants born to mothers with GDM, 221 (57.7%) were female, and the incidence of these infants was 1 in 155 live births. The risk of SGA siblings (RR, 1.88; 95% CI, [1.23–2.86]), low 1- and 5-min Apgar scores (RR,2.04 and 4.21; 95%CI [1.05–4.00] and [1.05–16.89], respectively), early thrombocytopenia (RR, 3.39; 95%CI, [1.33–8.64]), hypoglycemia(RR, 2.49; 95%CI, [1.55–3.98]), and hypoxic-ischemic encephalopathy (RR,5.61; 95%CI, [1.25–25.18]) were increased in SGA infants born to mothers with GDM compared to SGA infants born to mothers without GDM. SGA girls born to mothers with GDM had a significantly higher ratio of catch-up growth (CUG) (RR, 1.73; 95%CI, [1.18–2.54]) in the first year of life. These results show that genetic factors may be one of the etiologies of SGA infants born to mothers with GDM; and these infants have more adverse perinatal outcomes compared to SGA infants born to mothers without GDM. SGA girls born to mothers with GDM had accelerated CUG in the first year of life.
format Online
Article
Text
id pubmed-8517473
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85174732021-10-16 Demographic and Clinical Features of Small-for-Gestational-Age Infants Born to Mothers With Gestational Diabetes Mellitus Chen, Juncao Xiao, Huimin Yang, Yong Tang, Yaping Yang, Xiaoqi Zhang, Zhe Lu, Weineng Yao, Jie Huang, Longguang Liu, Xiaoping Zhou, Wei Front Pediatr Pediatrics We studied the demographic and clinical characteristic, risk factors, outcomes of full-term small-for-gestational-age (SGA) infants born to mothers with gestational diabetes mellitus (GDM) in China. A retrospective case-control study that included 1981 SGA infants was conducted; the demographic and clinical data between SGA infants born to mothers with and without GDM were compared. Of 383 SGA infants born to mothers with GDM, 221 (57.7%) were female, and the incidence of these infants was 1 in 155 live births. The risk of SGA siblings (RR, 1.88; 95% CI, [1.23–2.86]), low 1- and 5-min Apgar scores (RR,2.04 and 4.21; 95%CI [1.05–4.00] and [1.05–16.89], respectively), early thrombocytopenia (RR, 3.39; 95%CI, [1.33–8.64]), hypoglycemia(RR, 2.49; 95%CI, [1.55–3.98]), and hypoxic-ischemic encephalopathy (RR,5.61; 95%CI, [1.25–25.18]) were increased in SGA infants born to mothers with GDM compared to SGA infants born to mothers without GDM. SGA girls born to mothers with GDM had a significantly higher ratio of catch-up growth (CUG) (RR, 1.73; 95%CI, [1.18–2.54]) in the first year of life. These results show that genetic factors may be one of the etiologies of SGA infants born to mothers with GDM; and these infants have more adverse perinatal outcomes compared to SGA infants born to mothers without GDM. SGA girls born to mothers with GDM had accelerated CUG in the first year of life. Frontiers Media S.A. 2021-10-01 /pmc/articles/PMC8517473/ /pubmed/34660493 http://dx.doi.org/10.3389/fped.2021.741793 Text en Copyright © 2021 Chen, Xiao, Yang, Tang, Yang, Zhang, Lu, Yao, Huang, Liu and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Chen, Juncao
Xiao, Huimin
Yang, Yong
Tang, Yaping
Yang, Xiaoqi
Zhang, Zhe
Lu, Weineng
Yao, Jie
Huang, Longguang
Liu, Xiaoping
Zhou, Wei
Demographic and Clinical Features of Small-for-Gestational-Age Infants Born to Mothers With Gestational Diabetes Mellitus
title Demographic and Clinical Features of Small-for-Gestational-Age Infants Born to Mothers With Gestational Diabetes Mellitus
title_full Demographic and Clinical Features of Small-for-Gestational-Age Infants Born to Mothers With Gestational Diabetes Mellitus
title_fullStr Demographic and Clinical Features of Small-for-Gestational-Age Infants Born to Mothers With Gestational Diabetes Mellitus
title_full_unstemmed Demographic and Clinical Features of Small-for-Gestational-Age Infants Born to Mothers With Gestational Diabetes Mellitus
title_short Demographic and Clinical Features of Small-for-Gestational-Age Infants Born to Mothers With Gestational Diabetes Mellitus
title_sort demographic and clinical features of small-for-gestational-age infants born to mothers with gestational diabetes mellitus
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517473/
https://www.ncbi.nlm.nih.gov/pubmed/34660493
http://dx.doi.org/10.3389/fped.2021.741793
work_keys_str_mv AT chenjuncao demographicandclinicalfeaturesofsmallforgestationalageinfantsborntomotherswithgestationaldiabetesmellitus
AT xiaohuimin demographicandclinicalfeaturesofsmallforgestationalageinfantsborntomotherswithgestationaldiabetesmellitus
AT yangyong demographicandclinicalfeaturesofsmallforgestationalageinfantsborntomotherswithgestationaldiabetesmellitus
AT tangyaping demographicandclinicalfeaturesofsmallforgestationalageinfantsborntomotherswithgestationaldiabetesmellitus
AT yangxiaoqi demographicandclinicalfeaturesofsmallforgestationalageinfantsborntomotherswithgestationaldiabetesmellitus
AT zhangzhe demographicandclinicalfeaturesofsmallforgestationalageinfantsborntomotherswithgestationaldiabetesmellitus
AT luweineng demographicandclinicalfeaturesofsmallforgestationalageinfantsborntomotherswithgestationaldiabetesmellitus
AT yaojie demographicandclinicalfeaturesofsmallforgestationalageinfantsborntomotherswithgestationaldiabetesmellitus
AT huanglongguang demographicandclinicalfeaturesofsmallforgestationalageinfantsborntomotherswithgestationaldiabetesmellitus
AT liuxiaoping demographicandclinicalfeaturesofsmallforgestationalageinfantsborntomotherswithgestationaldiabetesmellitus
AT zhouwei demographicandclinicalfeaturesofsmallforgestationalageinfantsborntomotherswithgestationaldiabetesmellitus