Structural analysis and binding sites of inhibitors targeting the CD47/SIRPα interaction in anticancer therapy

Cluster of differentiation 47 (CD47)/signal regulatory protein alpha (SIRPα) is a negative innate immune checkpoint signaling pathway that restrains immunosurveillance and immune clearance, and thus has aroused wide interest in cancer immunotherapy. Blockade of the CD47/SIRPα signaling pathway shows...

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Detalles Bibliográficos
Autores principales: Huang, Bo, Bai, Zhaoshi, Ye, Xinyue, Zhou, Chenyu, Xie, Xiaolin, Zhong, Yuejiao, Lin, Kejiang, Ma, Lingman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517548/
https://www.ncbi.nlm.nih.gov/pubmed/34712395
http://dx.doi.org/10.1016/j.csbj.2021.09.036

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