Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs

The treatment of viral infections remains challenging, in particular in the face of emerging pathogens. Broad-spectrum antiviral drugs could potentially be used as a first line of defense. The RNA-dependent RNA polymerase (RdRp) of RNA viruses serves as a logical target for drug discovery and develo...

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Autores principales: Maheden, Kieran, Todd, Brendan, Gordon, Calvin J., Tchesnokov, Egor P., Götte, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517576/
https://www.ncbi.nlm.nih.gov/pubmed/34696837
http://dx.doi.org/10.1016/bs.enz.2021.07.002
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author Maheden, Kieran
Todd, Brendan
Gordon, Calvin J.
Tchesnokov, Egor P.
Götte, Matthias
author_facet Maheden, Kieran
Todd, Brendan
Gordon, Calvin J.
Tchesnokov, Egor P.
Götte, Matthias
author_sort Maheden, Kieran
collection PubMed
description The treatment of viral infections remains challenging, in particular in the face of emerging pathogens. Broad-spectrum antiviral drugs could potentially be used as a first line of defense. The RNA-dependent RNA polymerase (RdRp) of RNA viruses serves as a logical target for drug discovery and development efforts. Herein we discuss compounds that target RdRp of poliovirus, hepatitis C virus, influenza viruses, respiratory syncytial virus, and the growing data on coronaviruses. We focus on nucleotide analogs and mechanisms of action and resistance.
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spelling pubmed-85175762021-10-15 Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs Maheden, Kieran Todd, Brendan Gordon, Calvin J. Tchesnokov, Egor P. Götte, Matthias Enzymes Article The treatment of viral infections remains challenging, in particular in the face of emerging pathogens. Broad-spectrum antiviral drugs could potentially be used as a first line of defense. The RNA-dependent RNA polymerase (RdRp) of RNA viruses serves as a logical target for drug discovery and development efforts. Herein we discuss compounds that target RdRp of poliovirus, hepatitis C virus, influenza viruses, respiratory syncytial virus, and the growing data on coronaviruses. We focus on nucleotide analogs and mechanisms of action and resistance. Elsevier Inc. 2021 2021-10-15 /pmc/articles/PMC8517576/ /pubmed/34696837 http://dx.doi.org/10.1016/bs.enz.2021.07.002 Text en Copyright © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Maheden, Kieran
Todd, Brendan
Gordon, Calvin J.
Tchesnokov, Egor P.
Götte, Matthias
Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs
title Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs
title_full Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs
title_fullStr Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs
title_full_unstemmed Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs
title_short Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs
title_sort inhibition of viral rna-dependent rna polymerases with clinically relevant nucleotide analogs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517576/
https://www.ncbi.nlm.nih.gov/pubmed/34696837
http://dx.doi.org/10.1016/bs.enz.2021.07.002
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