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Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs

The treatment of viral infections remains challenging, in particular in the face of emerging pathogens. Broad-spectrum antiviral drugs could potentially be used as a first line of defense. The RNA-dependent RNA polymerase (RdRp) of RNA viruses serves as a logical target for drug discovery and develo...

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Detalles Bibliográficos
Autores principales:	Maheden, Kieran, Todd, Brendan, Gordon, Calvin J., Tchesnokov, Egor P., Götte, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517576/ https://www.ncbi.nlm.nih.gov/pubmed/34696837 http://dx.doi.org/10.1016/bs.enz.2021.07.002

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