Biomarkers for gastrointestinal adverse events related to thiopurine therapy

Thiopurines are immunomodulators used in the treatment of acute lymphoblastic leukemia and inflammatory bowel diseases. Adverse reactions to these agents are one of the main causes of treatment discontinuation or interruption. Myelosuppression is the most frequent adverse effect; however, approximat...

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Autores principales: Zudeh, Giulia, Franca, Raffaella, Stocco, Gabriele, Decorti, Giuliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517779/
https://www.ncbi.nlm.nih.gov/pubmed/34720526
http://dx.doi.org/10.3748/wjg.v27.i38.6348
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author Zudeh, Giulia
Franca, Raffaella
Stocco, Gabriele
Decorti, Giuliana
author_facet Zudeh, Giulia
Franca, Raffaella
Stocco, Gabriele
Decorti, Giuliana
author_sort Zudeh, Giulia
collection PubMed
description Thiopurines are immunomodulators used in the treatment of acute lymphoblastic leukemia and inflammatory bowel diseases. Adverse reactions to these agents are one of the main causes of treatment discontinuation or interruption. Myelosuppression is the most frequent adverse effect; however, approximately 5%-20% of patients develop gastrointestinal toxicity. The identification of biomarkers able to prevent and/or monitor these adverse reactions would be useful for clinicians for the proactive management of long-term thiopurine therapy. In this editorial, we discuss evidence supporting the use of PACSIN2, RAC1, and ITPA genes, in addition to TPMT and NUDT15, as possible biomarkers for thiopurine-related gastrointestinal toxicity.
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spelling pubmed-85177792021-10-28 Biomarkers for gastrointestinal adverse events related to thiopurine therapy Zudeh, Giulia Franca, Raffaella Stocco, Gabriele Decorti, Giuliana World J Gastroenterol Editorial Thiopurines are immunomodulators used in the treatment of acute lymphoblastic leukemia and inflammatory bowel diseases. Adverse reactions to these agents are one of the main causes of treatment discontinuation or interruption. Myelosuppression is the most frequent adverse effect; however, approximately 5%-20% of patients develop gastrointestinal toxicity. The identification of biomarkers able to prevent and/or monitor these adverse reactions would be useful for clinicians for the proactive management of long-term thiopurine therapy. In this editorial, we discuss evidence supporting the use of PACSIN2, RAC1, and ITPA genes, in addition to TPMT and NUDT15, as possible biomarkers for thiopurine-related gastrointestinal toxicity. Baishideng Publishing Group Inc 2021-10-14 2021-10-14 /pmc/articles/PMC8517779/ /pubmed/34720526 http://dx.doi.org/10.3748/wjg.v27.i38.6348 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Editorial
Zudeh, Giulia
Franca, Raffaella
Stocco, Gabriele
Decorti, Giuliana
Biomarkers for gastrointestinal adverse events related to thiopurine therapy
title Biomarkers for gastrointestinal adverse events related to thiopurine therapy
title_full Biomarkers for gastrointestinal adverse events related to thiopurine therapy
title_fullStr Biomarkers for gastrointestinal adverse events related to thiopurine therapy
title_full_unstemmed Biomarkers for gastrointestinal adverse events related to thiopurine therapy
title_short Biomarkers for gastrointestinal adverse events related to thiopurine therapy
title_sort biomarkers for gastrointestinal adverse events related to thiopurine therapy
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517779/
https://www.ncbi.nlm.nih.gov/pubmed/34720526
http://dx.doi.org/10.3748/wjg.v27.i38.6348
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