ADAMs family in kidney physiology and pathology

A disintegrin and metalloproteinases (ADAMs) family are proteolytic transmembrane proteases that modulate diverse cell functions and coordinate intercellular communication. ADAMs are responsible for regulating cell proliferation, differentiation, migration, and organ morphogenesis in kidney developm...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Huanhuan, Wang, Junni, Nie, Wanyun, Armando, Ines, Han, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517843/
https://www.ncbi.nlm.nih.gov/pubmed/34653870
http://dx.doi.org/10.1016/j.ebiom.2021.103628
_version_ 1784584097295761408
author Zhu, Huanhuan
Wang, Junni
Nie, Wanyun
Armando, Ines
Han, Fei
author_facet Zhu, Huanhuan
Wang, Junni
Nie, Wanyun
Armando, Ines
Han, Fei
author_sort Zhu, Huanhuan
collection PubMed
description A disintegrin and metalloproteinases (ADAMs) family are proteolytic transmembrane proteases that modulate diverse cell functions and coordinate intercellular communication. ADAMs are responsible for regulating cell proliferation, differentiation, migration, and organ morphogenesis in kidney development. Abnormally activated ADAMs drive inflammation and fibrosis in response to kidney diseases such as acute kidney injury, diabetic kidney disease, polycystic kidney disease, and chronic allograft nephropathy. ADAM10 and ADAM17, known as the most characterized members of ADAMs, are extensively investigated in kidney diseases. Notably, ADAM proteases have the potential to be targets for developing novel treatment approaches in kidney diseases.
format Online
Article
Text
id pubmed-8517843
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-85178432021-10-21 ADAMs family in kidney physiology and pathology Zhu, Huanhuan Wang, Junni Nie, Wanyun Armando, Ines Han, Fei EBioMedicine Review A disintegrin and metalloproteinases (ADAMs) family are proteolytic transmembrane proteases that modulate diverse cell functions and coordinate intercellular communication. ADAMs are responsible for regulating cell proliferation, differentiation, migration, and organ morphogenesis in kidney development. Abnormally activated ADAMs drive inflammation and fibrosis in response to kidney diseases such as acute kidney injury, diabetic kidney disease, polycystic kidney disease, and chronic allograft nephropathy. ADAM10 and ADAM17, known as the most characterized members of ADAMs, are extensively investigated in kidney diseases. Notably, ADAM proteases have the potential to be targets for developing novel treatment approaches in kidney diseases. Elsevier 2021-10-12 /pmc/articles/PMC8517843/ /pubmed/34653870 http://dx.doi.org/10.1016/j.ebiom.2021.103628 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Zhu, Huanhuan
Wang, Junni
Nie, Wanyun
Armando, Ines
Han, Fei
ADAMs family in kidney physiology and pathology
title ADAMs family in kidney physiology and pathology
title_full ADAMs family in kidney physiology and pathology
title_fullStr ADAMs family in kidney physiology and pathology
title_full_unstemmed ADAMs family in kidney physiology and pathology
title_short ADAMs family in kidney physiology and pathology
title_sort adams family in kidney physiology and pathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517843/
https://www.ncbi.nlm.nih.gov/pubmed/34653870
http://dx.doi.org/10.1016/j.ebiom.2021.103628
work_keys_str_mv AT zhuhuanhuan adamsfamilyinkidneyphysiologyandpathology
AT wangjunni adamsfamilyinkidneyphysiologyandpathology
AT niewanyun adamsfamilyinkidneyphysiologyandpathology
AT armandoines adamsfamilyinkidneyphysiologyandpathology
AT hanfei adamsfamilyinkidneyphysiologyandpathology

Ejemplares similares