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Searchable database of frequent R-groups in medicinal chemistry and their preferred replacements
In compound optimization, analogue series (ASs) are generated by introducing different R-groups (substituents, functional groups) at specific substitution sites. Systematic investigations of R-groups in medicinal chemistry have so far been rare. We have carried out a large-scale computational analys...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517848/ https://www.ncbi.nlm.nih.gov/pubmed/34692956 http://dx.doi.org/10.1016/j.dib.2021.107456 |